Reactome | ZNRF3 autoubiquitinates to promote its internalization

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ZNRF3 autoubiquitinates to promote its internalization Show undefined attributes

authored	[InstanceEdit:4610796] Rothfels, K, 2013-09-23
catalystActivity	[CatalystActivity:4641247] ubiquitin protein ligase activity of RSPO:LGR:ZNRF3,RNF43 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:4641245] Rothfels, K, 2013-09-27
dbId	4641246
displayName	ZNRF3 autoubiquitinates to promote its internalization
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-4641263] Regulation of FZD by ubiquitination - Homo sapiens
input	[Complex:R-HSA-4641203] RSPO:LGR:ZNRF3,RNF43 [plasma membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4641102] ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ZNRF3 autoubiquitinates to promote its internalization
negativePrecedingEvent	[NegativePrecedingEvent:9965524] Abundant Molecules: USP34 deubiquitinates AXIN1,AXIN2 [NegativePrecedingEvent:9965528] Abundant Molecules: USP8 deubiquitinates FZD to potentiate WNT signaling [NegativePrecedingEvent:9965545] Abundant Molecules: Ub-RibC-AXIN is degraded by the proteasome [NegativePrecedingEvent:9965546] Abundant Molecules: Ubiquitinated AXIN is degraded by the proteasome [NegativePrecedingEvent:9965502] Abundant Molecules: Ubiquitinated DVL is degraded by the proteasome [NegativePrecedingEvent:9965522] Abundant Molecules: Ubiquitinated DVL1 is degraded by the proteasome
orthologousEvent	[Reaction:R-GGA-4641246] ZNRF3 autoubiquitinates to promote its internalization - Gallus gallus [Reaction:R-XTR-4641246] ZNRF3 autoubiquitinates to promote its internalization - Xenopus tropicalis [Reaction:R-DRE-4641246] ZNRF3 autoubiquitinates to promote its internalization - Danio rerio [Reaction:R-SSC-4641246] ZNRF3 autoubiquitinates to promote its internalization - Sus scrofa [Reaction:R-BTA-4641246] ZNRF3 autoubiquitinates to promote its internalization - Bos taurus [Reaction:R-CFA-4641246] ZNRF3 autoubiquitinates to promote its internalization - Canis familiaris [Reaction:R-RNO-4641246] ZNRF3 autoubiquitinates to promote its internalization - Rattus norvegicus [Reaction:R-MMU-4641246] ZNRF3 autoubiquitinates to promote its internalization - Mus musculus
output	[Complex:R-HSA-4641211] RSPO:LGR:ub-ZNRF3,RNF43 [plasma membrane]
precedingEvent	[Reaction:R-HSA-4641205] RSPO:LGR binds ZNRF3 - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4641246
summation	[Summation:4641173] Mutation of the RING domain of ZNRF3 abrogates membrane clea...

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(hasEvent)

[Pathway:R-HSA-4641263] Regulation of FZD by ubiquitination