Reactome | PIAS1 SUMOylates SATB1 with SUMO1

Schema > Reaction > Entries

PIAS1 SUMOylates SATB1 with SUMO1 Show undefined attributes

authored	[InstanceEdit:4570563] May, B, 2013-09-21
catalystActivity	[CatalystActivity:3247478] SUMO transferase activity of PIAS1 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643901] SUMO transferase activity of PIAS1 [nucleoplasm] Transcription factor Sp3 is silenced through SUMO modification by PIAS1
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4615844] May, B, 2013-09-27
dbId	4615905
displayName	PIAS1 SUMOylates SATB1 with SUMO1
edited	[InstanceEdit:4570563] May, B, 2013-09-21
eventOf	[Pathway:R-HSA-4551638] SUMOylation of chromatin organization proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-201593] SATB1 [nucleoplasm] [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4616023] SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage [LiteratureReference:4615896] Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PIAS1 SUMOylates SATB1 with SUMO1
orthologousEvent	[Reaction:R-CEL-4615905] PIAS1 SUMOylates SATB1 with SUMO1 - Caenorhabditis elegans [Reaction:R-GGA-4615905] PIAS1 SUMOylates SATB1 with SUMO1 - Gallus gallus [Reaction:R-DRE-4615905] PIAS1 SUMOylates SATB1 with SUMO1 - Danio rerio [Reaction:R-SSC-4615905] PIAS1 SUMOylates SATB1 with SUMO1 - Sus scrofa [Reaction:R-BTA-4615905] PIAS1 SUMOylates SATB1 with SUMO1 - Bos taurus [Reaction:R-RNO-4615905] PIAS1 SUMOylates SATB1 with SUMO1 - Rattus norvegicus [Reaction:R-MMU-4615905] PIAS1 SUMOylates SATB1 with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4615954] monoSUMO1-K744-SATB1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8956382] Lu, Jian, 2017-01-22 [InstanceEdit:8956359] Matunis, Michael J, 2017-01-22 [InstanceEdit:8956371] Yang, Wei-Chih, 2017-01-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4615905
summation	[Summation:4616021] PIAS1 SUMOylates SATB1 at lysine-744 with SUMO1 (Tan et al. ...
updateTrackers	[UpdateTracker:9774923] Update Tracker - [Reaction:4615905] PIAS1 SUMOylates SATB1 with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9774923] Update Tracker - [Reaction:4615905] PIAS1 SUMOylates SATB1 with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-4551638] SUMOylation of chromatin organization proteins