Reactome | RANBP2 SUMOylates RANBP2 with SUMO1

Schema > Reaction > Entries

RANBP2 SUMOylates RANBP2 with SUMO1 Show undefined attributes

authored	[InstanceEdit:4551677] May, B, 2013-09-13
catalystActivity	[CatalystActivity:3000418] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
catalystActivityReference	[CatalystActivityReference:9644133] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope] Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection
category	transition
compartment	[Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm
created	[InstanceEdit:4551601] May, B, 2013-09-14
dbId	4551649
displayName	RANBP2 SUMOylates RANBP2 with SUMO1
edited	[InstanceEdit:4551677] May, B, 2013-09-13
eventOf	[Pathway:R-HSA-4085377] SUMOylation of SUMOylation proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2993756] RANBP2 [nuclear envelope] 3 × [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3000453] The nucleoporin RanBP2 has SUMO1 E3 ligase activity [LiteratureReference:4551753] Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction [LiteratureReference:4551652] The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	RANBP2 SUMOylates RANBP2 with SUMO1
orthologousEvent	[Reaction:R-SPO-4551649] RANBP2 SUMOylates RANBP2 with SUMO1 - Schizosaccharomyces pombe [Reaction:R-GGA-4551649] RANBP2 SUMOylates RANBP2 with SUMO1 - Gallus gallus [Reaction:R-SSC-4551649] RANBP2 SUMOylates RANBP2 with SUMO1 - Sus scrofa [Reaction:R-BTA-4551649] RANBP2 SUMOylates RANBP2 with SUMO1 - Bos taurus [Reaction:R-RNO-4551649] RANBP2 SUMOylates RANBP2 with SUMO1 - Rattus norvegicus [Reaction:R-MMU-4551649] RANBP2 SUMOylates RANBP2 with SUMO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4551599] monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] 3 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608076] Niskanen, Einari, 2018-05-09 [InstanceEdit:9615865] Niskanen, Einari, 2018-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4551649
summation	[Summation:4551614] RANBP2 SUMOylates RANBP2 at lysine-2592, lysine-2650, and ly...
updateTrackers	[UpdateTracker:9774848] Update Tracker - [Reaction:4551649] RANBP2 SUMOylates RANBP2 with SUMO1 - v80:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9774848] Update Tracker - [Reaction:4551649] RANBP2 SUMOylates RANBP2 with SUMO1 - v80:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-4085377] SUMOylation of SUMOylation proteins