Reactome | IL12A:IL12B [extracellular region]

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-8950686] IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-447226] Interleukin-12 binds Interleukin-12 receptor - Homo sapiens
created	[InstanceEdit:447133] Jupe, S, 2009-11-20
dbId	447102
displayName	IL12A:IL12B [extracellular region]
hasComponent	[EntityWithAccessionedSequence:R-HSA-447212] IL12A [extracellular region] [EntityWithAccessionedSequence:R-HSA-447181] IL12B [extracellular region]
inDisease	false
inferredTo	[Complex:R-MMU-447102] IL12A:IL12B [extracellular region] - Mus musculus [Complex:R-RNO-447102] IL12A:IL12B [extracellular region] - Rattus norvegicus [Complex:R-CFA-447102] IL12A:IL12B [extracellular region] - Canis familiaris [Complex:R-BTA-447102] IL12A:IL12B [extracellular region] - Bos taurus [Complex:R-SSC-447102] IL12A:IL12B [extracellular region] - Sus scrofa [Complex:R-XTR-447102] IL12A:IL12B [extracellular region] - Xenopus tropicalis [Complex:R-GGA-447102] IL12A:IL12B [extracellular region] - Gallus gallus
isChimeric	false
literatureReference	[LiteratureReference:8949834] The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells
maxDepth	2
memberOf	[DefinedSet:R-HSA-6789357] IL13-downregulated proteins [extracellular region] - Homo sapiens
modified	[InstanceEdit:8949833] Jupe, Steve, 2016-11-29
name	IL12A:IL12B IL12 Interleukin-12
producedByEvent	[Reaction:R-HSA-8950347] IL12A:IL12B translocates from late endosome lumen to extracellular region - Homo sapiens [Reaction:R-HSA-8950128] Interleukin-12 dissociates from Interleukin-12 receptor - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-447102
updateTrackers	[UpdateTracker:9896256] Update Tracker - [Complex:447102] IL12A:IL12B [extracellular region] - v60:[addLiteratureReference]

(updatedInstance)	[UpdateTracker:9896256] Update Tracker - [Complex:447102] IL12A:IL12B [extracellular region] - v60:[addLiteratureReference]
(input)	[Reaction:R-HSA-447226] Interleukin-12 binds Interleukin-12 receptor
(output)	[Reaction:R-HSA-8950128] Interleukin-12 dissociates from Interleukin-12 receptor [Reaction:R-HSA-8950347] IL12A:IL12B translocates from late endosome lumen to extracellular region
(hasComponent)	[Complex:R-HSA-8950686] IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] [Complex:R-HSA-8950227] IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] [Complex:R-HSA-8981056] IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [cytosol] [Complex:R-HSA-8950116] IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane]
(hasMember)	[DefinedSet:R-HSA-6789357] IL13-downregulated proteins [extracellular region]

IL12A:IL12B [extracellular region] Show undefined attributes

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