Reactome | p-S15,S20-TP53 Tetramer:PMAIP1 Gene [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4331328] Orlic-Milacic, M, 2013-08-16
dbId	4331332
displayName	p-S15,S20-TP53 Tetramer:PMAIP1 Gene [nucleoplasm]
hasComponent	[Complex:R-HSA-3222171] p-S15,S20-TP53 Tetramer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4331342] PMAIP1 Gene [nucleoplasm]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:140442] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53 [LiteratureReference:140387] Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
maxDepth	3
modified	[InstanceEdit:8856056] Orlic-Milacic, Marija, 2016-02-08
name	p-S15,S20-TP53 Tetramer:PMAIP1 Gene
positivelyRegulates	[PositiveGeneExpressionRegulation:R-HSA-159038] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:PMAIP1 Gene [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-4331331] TP53 binds the PMAIP1 (NOXA) promoter - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-4331332
updateTrackers	[UpdateTracker:9893464] Update Tracker - [Complex:4331332] p-S15,S20-TP53 Tetramer:PMAIP1 Gene [nucleoplasm] - v56:[add_removeHasComponent, modifyName] [UpdateTracker:9892946] Update Tracker - [Complex:4331332] p-S15,S20-TP53 Tetramer:PMAIP1 Gene [nucleoplasm] - v54:[add_removeHasComponent, modifyName]

(updatedInstance)	[UpdateTracker:9893464] Update Tracker - [Complex:4331332] p-S15,S20-TP53 Tetramer:PMAIP1 Gene [nucleoplasm] - v56:[add_removeHasComponent, modifyName] [UpdateTracker:9892946] Update Tracker - [Complex:4331332] p-S15,S20-TP53 Tetramer:PMAIP1 Gene [nucleoplasm] - v54:[add_removeHasComponent, modifyName]
(regulator)	[PositiveGeneExpressionRegulation:R-HSA-159038] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:PMAIP1 Gene [nucleoplasm]'
(output)	[Reaction:R-HSA-4331331] TP53 binds the PMAIP1 (NOXA) promoter