Reactome | SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol

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SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
catalystActivity	[CatalystActivity:426160] sodium:chloride symporter activity of SLC12A3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
crossReference	[DatabaseIdentifier:12668160] RHEA:73887 [DatabaseIdentifier:9959218] RHEA:73888
dbId	426130
diseaseReaction	[FailedReaction:R-HSA-5623705] Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol - Homo sapiens
displayName	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol
edited	[InstanceEdit:426114] Jassal, Bijay, 2009-06-12
eventOf	[Pathway:R-HSA-426117] Cation-coupled Chloride cotransporters - Homo sapiens
input	[SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:426144] Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3) [LiteratureReference:426108] Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol Na+/Cl- cotransport
orthologousEvent	[Reaction:R-SCE-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Saccharomyces cerevisiae [Reaction:R-SPO-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Schizosaccharomyces pombe [Reaction:R-CEL-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-DME-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-GGA-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Gallus gallus [Reaction:R-XTR-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-DRE-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Danio rerio [Reaction:R-SSC-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Sus scrofa [Reaction:R-BTA-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Bos taurus [Reaction:R-CFA-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Canis familiaris [Reaction:R-RNO-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Rattus norvegicus [Reaction:R-MMU-426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-426130
summation	[Summation:426098] The SLC12A3 gene encodes for the Thiazide-sensitive sodium-c...
updateTrackers	[UpdateTracker:9785911] Update Tracker - [Reaction:426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - v51:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785911] Update Tracker - [Reaction:426130] SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol - v51:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5623705] Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol
(hasEvent)	[Pathway:R-HSA-426117] Cation-coupled Chloride cotransporters