Reactome | Tight junction interactions

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Tight junction interactions Show undefined attributes

authored	[InstanceEdit:421262] Matthews, L, 2009-05-15 19:26:33
created	[InstanceEdit:420030] Matthews, L, 2009-05-10 21:00:05
dbId	420029
displayName	Tight junction interactions
edited	[InstanceEdit:421267] Matthews, L, 2009-05-12 19:53:20 [InstanceEdit:433712] Matthews, L, 2009-08-19
eventOf	[Pathway:R-HSA-421270] Cell-cell junction organization - Homo sapiens
figure	[Figure:421396] /figures/tightjunctions.jpg
goBiologicalProcess	[GO_BiologicalProcess:434190] bicellular tight junction assembly
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-420019] Claudins create paired strands through homophilic and heterophilic cis and trans interactions - Homo sapiens [Reaction:R-HSA-419981] Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions - Homo sapiens [Reaction:R-HSA-420661] Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:420027] Organization of multiprotein complexes at cell-cell junctions [LiteratureReference:432826] Signalling to and from tight junctions [LiteratureReference:432836] Epithelial tight junctions, gene expression and nucleo-junctional interplay [LiteratureReference:432815] Multifunctional strands in tight junctions [LiteratureReference:432840] ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Tight junction interactions
orthologousEvent	[Pathway:R-SSC-420029] Tight junction interactions - Sus scrofa [Pathway:R-GGA-420029] Tight junction interactions - Gallus gallus [Pathway:R-DRE-420029] Tight junction interactions - Danio rerio [Pathway:R-BTA-420029] Tight junction interactions - Bos taurus [Pathway:R-CFA-420029] Tight junction interactions - Canis familiaris [Pathway:R-RNO-420029] Tight junction interactions - Rattus norvegicus [Pathway:R-MMU-420029] Tight junction interactions - Mus musculus
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434154] Ebnet, K, 2009-08-26
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-420029
summation	[Summation:420028] Tight junctions (TJs) are the most apical component of the e...
updateTrackers	[UpdateTracker:9789728] Update Tracker - [Pathway:420029] Tight junction interactions - v37:[modifyText, updateContainedRLE] [UpdateTracker:9782659] Update Tracker - [Pathway:420029] Tight junction interactions - v59:[updateContainedRLE] [UpdateTracker:9791371] Update Tracker - [Pathway:420029] Tight junction interactions - v31:[modifyText, updateContainedRLE] [UpdateTracker:9786545] Update Tracker - [Pathway:420029] Tight junction interactions - v49:[modifyText] [UpdateTracker:9775206] Update Tracker - [Pathway:420029] Tight junction interactions - v80:[updateContainedRLE] [UpdateTracker:9776352] Update Tracker - [Pathway:420029] Tight junction interactions - v76:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9789728] Update Tracker - [Pathway:420029] Tight junction interactions - v37:[modifyText, updateContainedRLE]
[UpdateTracker:9782659] Update Tracker - [Pathway:420029] Tight junction interactions - v59:[updateContainedRLE]
[UpdateTracker:9791371] Update Tracker - [Pathway:420029] Tight junction interactions - v31:[modifyText, updateContainedRLE]
[UpdateTracker:9786545] Update Tracker - [Pathway:420029] Tight junction interactions - v49:[modifyText]
[UpdateTracker:9775206] Update Tracker - [Pathway:420029] Tight junction interactions - v80:[updateContainedRLE]
[UpdateTracker:9776352] Update Tracker - [Pathway:420029] Tight junction interactions - v76:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-421270] Cell-cell junction organization

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