Reactome | FFAR1:FFAR1 ligands activate Gq

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FFAR1:FFAR1 ligands activate Gq Show undefined attributes

authored	[InstanceEdit:425809] May, B, 2009-06-08
catalystActivity	[CatalystActivity:416526] guanyl-nucleotide exchange factor activity of FFAR1:FFAR1 ligands [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:416527] May, B, 2009-03-29 09:35:53
dbId	416530
displayName	FFAR1:FFAR1 ligands activate Gq
edited	[InstanceEdit:425809] May, B, 2009-06-08
eventOf	[Pathway:R-HSA-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Homo sapiens
followingEvent	[Reaction:R-HSA-400027] Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma - Homo sapiens
input	[Complex:R-HSA-399992] G-alpha(q)11,14,15,Q:GDP:G-beta:G-gamma [plasma membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:434599] The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1 [LiteratureReference:434600] Role of GPR40 in fatty acid action on the beta cell line INS-1E [LiteratureReference:400408] Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release [LiteratureReference:400438] Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40 [LiteratureReference:400424] Fatty acid signaling in the beta-cell and insulin secretion [LiteratureReference:434298] The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids [LiteratureReference:400409] GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo [LiteratureReference:400442] Free fatty acid receptors and drug discovery [LiteratureReference:400435] Glycerolipid metabolism and signaling in health and disease
maxDepth	1
modified	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
name	FFAR1:FFAR1 ligands activate Gq
orthologousEvent	[Reaction:R-BTA-416530] FFAR1:FFAR1 ligands activate Gq - Bos taurus [Reaction:R-CFA-416530] FFAR1:FFAR1 ligands activate Gq - Canis familiaris [Reaction:R-RNO-416530] FFAR1:FFAR1 ligands activate Gq - Rattus norvegicus [Reaction:R-MMU-416530] FFAR1:FFAR1 ligands activate Gq - Mus musculus
output	[Complex:R-HSA-399987] G-alpha(q)11,14,15,Q:G-beta:G-gamma [plasma membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol]
precedingEvent	[Reaction:R-HSA-400434] FFAR1 binds fatty acids - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:435287] Kebede, M, 2009-09-09 [InstanceEdit:435289] Poitout, V, 2009-09-09 [InstanceEdit:443072] Madiraju, MS, 2009-10-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-416530
summation	[Summation:426568] FFAR1 (GPR40) is a G-protein coupled receptor. Based on stu...
updateTrackers	[UpdateTracker:9790613] Update Tracker - [Reaction:416530] FFAR1:FFAR1 ligands activates Gq - v33:[addCatalystActivity, add_removeInput, add_removeOutput] [UpdateTracker:9864101] Update Tracker - [Reaction:416530] FFAR1:FFAR1 ligands activate Gq - v88:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790613] Update Tracker - [Reaction:416530] FFAR1:FFAR1 ligands activates Gq - v33:[addCatalystActivity, add_removeInput, add_removeOutput] [UpdateTracker:9864101] Update Tracker - [Reaction:416530] FFAR1:FFAR1 ligands activate Gq - v88:[modifyText]
(hasEvent)	[Pathway:R-HSA-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
(precedingEvent)	[Reaction:R-HSA-400027] Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma

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