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Free fatty acids regulate insulin secretion
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authored
[InstanceEdit:425809] May, B, 2009-06-08
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:400413] May, B, 2009-03-24 03:18:13
dbId
400451
displayName
Free fatty acids regulate insulin secretion
edited
[InstanceEdit:425809] May, B, 2009-06-08
eventOf
[Pathway:R-HSA-422356] Regulation of insulin secretion - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:262055] positive regulation of insulin secretion
hasDiagram
false
hasEHLD
false
hasEvent
[Pathway:R-HSA-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion - Homo sapiens
[Pathway:R-HSA-434313] Intracellular metabolism of fatty acids regulates insulin secretion - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022-06-09
literatureReference
[LiteratureReference:400426] A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli
[LiteratureReference:400424] Fatty acid signaling in the beta-cell and insulin secretion
[LiteratureReference:400442] Free fatty acid receptors and drug discovery
[LiteratureReference:400409] GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo
[LiteratureReference:400435] Glycerolipid metabolism and signaling in health and disease
maxDepth
3
modified
[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name
Free fatty acids regulate insulin secretion
orthologousEvent
[Pathway:R-SCE-400451] Free fatty acids regulate insulin secretion - Saccharomyces cerevisiae
[Pathway:R-SPO-400451] Free fatty acids regulate insulin secretion - Schizosaccharomyces pombe
[Pathway:R-DDI-400451] Free fatty acids regulate insulin secretion - Dictyostelium discoideum
[Pathway:R-CEL-400451] Free fatty acids regulate insulin secretion - Caenorhabditis elegans
[Pathway:R-DME-400451] Free fatty acids regulate insulin secretion - Drosophila melanogaster
[Pathway:R-GGA-400451] Free fatty acids regulate insulin secretion - Gallus gallus
[Pathway:R-XTR-400451] Free fatty acids regulate insulin secretion - Xenopus tropicalis
[Pathway:R-DRE-400451] Free fatty acids regulate insulin secretion - Danio rerio
[Pathway:R-SSC-400451] Free fatty acids regulate insulin secretion - Sus scrofa
[Pathway:R-BTA-400451] Free fatty acids regulate insulin secretion - Bos taurus
[Pathway:R-CFA-400451] Free fatty acids regulate insulin secretion - Canis familiaris
[Pathway:R-RNO-400451] Free fatty acids regulate insulin secretion - Rattus norvegicus
[Pathway:R-MMU-400451] Free fatty acids regulate insulin secretion - Mus musculus
releaseDate
2009-09-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:435289] Poitout, V, 2009-09-09
[InstanceEdit:435287] Kebede, M, 2009-09-09
[InstanceEdit:443072] Madiraju, MS, 2009-10-02
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-400451
summation
[Summation:400414] Free fatty acids augment the glucose-triggered secretion of ...
updateTrackers
[UpdateTracker:9775931] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v78:[updateIndirectRLE]
[UpdateTracker:9788023] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v44:[updateIndirectRLE]
[UpdateTracker:9864009] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v88:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9791357] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v31:[modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9774796] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v81:[updateContainedPathway]
[UpdateTracker:9790771] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v33:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9778040] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v68:[addHasEvent, updateContainedPathway]
Referrals
(updatedInstance)
[UpdateTracker:9775931] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v78:[updateIndirectRLE]
[UpdateTracker:9788023] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v44:[updateIndirectRLE]
[UpdateTracker:9864009] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v88:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9791357] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v31:[modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9774796] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v81:[updateContainedPathway]
[UpdateTracker:9790771] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v33:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9778040] Update Tracker - [Pathway:400451] Free fatty acids regulate insulin secretion - v68:[addHasEvent, updateContainedPathway]
(hasEvent)
[Pathway:R-HSA-422356] Regulation of insulin secretion
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