Reactome | Formation of tubulin folding intermediates by CCT/TriC

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Formation of tubulin folding intermediates by CCT/TriC Show undefined attributes

authored	[InstanceEdit:387111] Matthews, L, 2008-12-01 04:46:41
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:389975] Matthews, L, 2009-01-21 19:24:07
dbId	389960
displayName	Formation of tubulin folding intermediates by CCT/TriC
edited	[InstanceEdit:391466] Matthews, L, 2009-02-21 04:38:35
eventOf	[Pathway:R-HSA-389958] Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding - Homo sapiens
followingEvent	[Pathway:R-HSA-389977] Post-chaperonin tubulin folding pathway - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:7977] protein folding
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-389961] ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex - Homo sapiens [Reaction:R-HSA-389954] Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2011-09-30
literatureReference	[LiteratureReference:391797] Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits [LiteratureReference:391536] Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors [LiteratureReference:391419] Two cofactors and cytoplasmic chaperonin are required for the folding of alpha- and beta-tubulin [LiteratureReference:391523] Type II chaperonins, prefoldin, and the tubulin-specific chaperones
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Formation of tubulin folding intermediates by CCT/TriC
precedingEvent	[Pathway:R-HSA-389957] Prefoldin mediated transfer of substrate to CCT/TriC - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:389965] Cowan, NJ, 2009-01-21 16:47:24
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-389960
summation	[Summation:391772] TriC/CCT forms a binary complex with unfolded alpha- or beta...
updateTrackers	[UpdateTracker:9789236] Update Tracker - [Pathway:389960] Formation of tubulin folding intermediates by CCT/TriC - v38:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9789236] Update Tracker - [Pathway:389960] Formation of tubulin folding intermediates by CCT/TriC - v38:[addLiteratureReference]
(precedingEvent)	[Pathway:R-HSA-389977] Post-chaperonin tubulin folding pathway
(hasEvent)	[Pathway:R-HSA-389958] Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

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