Reactome | isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+

Schema > Reaction > Entries

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ Show undefined attributes

authored	[InstanceEdit:389547] D'Eustachio, P, 2009-01-07 23:39:54
catalystActivity	[CatalystActivity:389544] isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [peroxisomal matrix]
catalystActivityReference	[CatalystActivityReference:9643511] isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [peroxisomal matrix] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:389551] D'Eustachio, P, 2009-01-07 23:42:02
crossReference	[DatabaseIdentifier:12667540] RHEA:19630
dbId	389550
displayName	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
edited	[InstanceEdit:389547] D'Eustachio, P, 2009-01-07 23:39:54
eventOf	[Pathway:R-HSA-389542] NADPH regeneration - Homo sapiens
followingEvent	[Reaction:R-HSA-389639] phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 - Homo sapiens [Reaction:R-HSA-390347] Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane - Homo sapiens
input	[SimpleEntity:R-ALL-389548] ISCIT [peroxisomal matrix] [SimpleEntity:R-ALL-389556] NADP+ [peroxisomal matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389555] Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity [LiteratureReference:389560] The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
orthologousEvent	[Reaction:R-SCE-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Saccharomyces cerevisiae [Reaction:R-SPO-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Schizosaccharomyces pombe [Reaction:R-DDI-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Dictyostelium discoideum [Reaction:R-CEL-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Caenorhabditis elegans [Reaction:R-DME-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Drosophila melanogaster [Reaction:R-GGA-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Gallus gallus [Reaction:R-XTR-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Xenopus tropicalis [Reaction:R-DRE-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Danio rerio [Reaction:R-SSC-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Sus scrofa [Reaction:R-BTA-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Bos taurus [Reaction:R-CFA-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Canis familiaris [Reaction:R-RNO-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Rattus norvegicus [Reaction:R-MMU-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Mus musculus
output	[SimpleEntity:R-ALL-389537] 2OG [peroxisomal matrix] [SimpleEntity:R-ALL-389536] CO2 [peroxisomal matrix] [SimpleEntity:R-ALL-193465] H+ [peroxisomal matrix] [SimpleEntity:R-ALL-113602] NADPH [peroxisomal matrix]
precedingEvent	[Reaction:R-HSA-390347] Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:392190] Jassal, Bijay, 2009-02-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389550
summation	[Summation:389541] Peroxisomal IDH1 (isocitrate dehydrogenase 1) homodimer cata...

Referrals

(hasEvent)	[Pathway:R-HSA-389542] NADPH regeneration
(precedingEvent)	[Reaction:R-HSA-389639] phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 [Reaction:R-HSA-390347] Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane

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