Reactome | UNC-5 binds Netrin-1

Schema > Reaction > Entries

UNC-5 binds Netrin-1 Show undefined attributes

authored	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:373749] Garapati, P V, 2008-07-16 14:41:53
dbId	373751
displayName	UNC-5 binds Netrin-1
edited	[InstanceEdit:374705] Garapati, P V, 2008-07-30 10:24:23
eventOf	[Pathway:R-HSA-418886] Netrin mediated repulsion signals - Homo sapiens
followingEvent	[Reaction:R-HSA-373713] DCC heterodimerizes with UNC-5:Netrin-1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-373624] NTN1 [extracellular region] [DefinedSet:R-HSA-373650] UNC5 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9928277] Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation [LiteratureReference:9928280] Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin [LiteratureReference:9928281] The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue
maxDepth	1
modified	[InstanceEdit:9928273] Garapati, Phani Vijay, 2024-11-13
name	UNC-5 binds Netrin-1
output	[Complex:R-HSA-373660] NTN1:UNC5 [plasma membrane]
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:513006] Cooper, HM, 2010-02-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-373751
summation	[Summation:373600] UNC-5 receptors interact with netrins and mediate the short-...
updateTrackers	[UpdateTracker:9928500] Update Tracker - [Reaction:373751] UNC-5 binds Netrin-1 - v91:[removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9928500] Update Tracker - [Reaction:373751] UNC-5 binds Netrin-1 - v91:[removeLiteratureReference]
(precedingEvent)	[Reaction:R-HSA-373713] DCC heterodimerizes with UNC-5:Netrin-1
(hasEvent)	[Pathway:R-HSA-418886] Netrin mediated repulsion signals