Reactome | Notch-HLH transcription pathway

Schema > Pathway > Entries

Notch-HLH transcription pathway Show undefined attributes

authored	[InstanceEdit:212387] Caudy, M, 2008-02-08 22:45:45
created	[InstanceEdit:350055] Caudy, M, 2008-05-13 22:42:06
dbId	350054
displayName	Notch-HLH transcription pathway
edited	[InstanceEdit:212387] Caudy, M, 2008-02-08 22:45:45
eventOf	[Pathway:R-HSA-212436] Generic Transcription Pathway - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17841] transcription initiation at RNA polymerase II promoter
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-350058] Formation of CSL NCOR corepressor complex - Homo sapiens [Reaction:R-HSA-212356] Formation of CSL-NICD coactivator complex - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:351550] A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling [LiteratureReference:351559] Cloning and characterization of a histone deacetylase, HDAC9 [LiteratureReference:351548] Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA [LiteratureReference:351524] Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors [LiteratureReference:351558] JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2) [LiteratureReference:351521] MEF-2 function is modified by a novel co-repressor, MITR [LiteratureReference:351538] Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex [LiteratureReference:351516] Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover [LiteratureReference:163864] Notch signaling activity [LiteratureReference:157129] Notch signaling: from the outside in [LiteratureReference:212872] Notch signalling in vertebrate neural development [LiteratureReference:212885] Notch signalling: a simple pathway becomes complex [LiteratureReference:351518] SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway [LiteratureReference:351549] SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function [LiteratureReference:351529] Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex [LiteratureReference:351566] p300 acts as a transcriptional coactivator for mammalian Notch-1
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Notch-HLH transcription pathway
orthologousEvent	[Pathway:R-DME-350054] Notch-HLH transcription pathway - Drosophila melanogaster [Pathway:R-GGA-350054] Notch-HLH transcription pathway - Gallus gallus [Pathway:R-SSC-350054] Notch-HLH transcription pathway - Sus scrofa [Pathway:R-BTA-350054] Notch-HLH transcription pathway - Bos taurus [Pathway:R-CFA-350054] Notch-HLH transcription pathway - Canis familiaris [Pathway:R-RNO-350054] Notch-HLH transcription pathway - Rattus norvegicus [Pathway:R-MMU-350054] Notch-HLH transcription pathway - Mus musculus
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-350054
summation	[Summation:350071] THE NOTCH-HLH TRANSCRIPTION PATHWAY: Notch ...
updateTrackers	[UpdateTracker:9791577] Update Tracker - [Pathway:350054] Notch-HLH transcription pathway - v28:[removeHasEvent] [UpdateTracker:9787853] Update Tracker - [Pathway:350054] Notch-HLH transcription pathway - v44:[updateContainedRLE] [UpdateTracker:9782592] Update Tracker - [Pathway:350054] Notch-HLH transcription pathway - v59:[removeLiteratureReference] [UpdateTracker:9781495] Update Tracker - [Pathway:350054] Notch-HLH transcription pathway - v61:[updateContainedRLE] [UpdateTracker:9778170] Update Tracker - [Pathway:350054] Notch-HLH transcription pathway - v68:[addHasEvent, updateContainedRLE]

Referrals

(updatedInstance)

(hasEvent)

[Pathway:R-HSA-212436] Generic Transcription Pathway

Cite Us!