Reactome | TLE1 tetramer [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9930709] HDAC1,(HDAC2):TLE1:ZEB1:CDH1 gene [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9930711] ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter - Homo sapiens
created	[InstanceEdit:3299549] Rothfels, K, 2013-04-18
dbId	3299557
displayName	TLE1 tetramer [nucleoplasm]
hasComponent	4 × [EntityWithAccessionedSequence:R-HSA-212327] TLE1 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-3299557] TLE1 tetramer [nucleoplasm] - Mus musculus [Complex:R-RNO-3299557] TLE1 tetramer [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-3299557] TLE1 tetramer [nucleoplasm] - Canis familiaris [Complex:R-BTA-3299557] TLE1 tetramer [nucleoplasm] - Bos taurus [Complex:R-SSC-3299557] TLE1 tetramer [nucleoplasm] - Sus scrofa [Complex:R-XTR-3299557] TLE1 tetramer [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-3299557] TLE1 tetramer [nucleoplasm] - Gallus gallus [Complex:R-DME-3299557] TLE1 tetramer [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-3299557] TLE1 tetramer [nucleoplasm] - Caenorhabditis elegans
isChimeric	false
literatureReference	[LiteratureReference:208367] Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
maxDepth	2
memberOf	[DefinedSet:R-HSA-3299565] TLE tetramer [nucleoplasm] - Homo sapiens
name	TLE1 tetramer
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-3299557

(input)	[Reaction:R-HSA-9930711] ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter
(hasComponent)	[Complex:R-HSA-9930709] HDAC1,(HDAC2):TLE1:ZEB1:CDH1 gene [nucleoplasm] [Complex:R-HSA-3299553] TLE1:HDAC1 [nucleoplasm]
(activeUnit)	[NegativeGeneExpressionRegulation:9815610] Negative gene expression regulation by 'ZEB1:CDH1 gene, SMARCA4:ZEB1:CDH1 gene, HDAC1,(HDAC2):TLE1:ZEB1:CDH1 gene, (SETD8:ZEB1:CDH1 gene, SIRT1:MPHOSPH8:ZEB1:CDH1 gene) [nucleoplasm]'
(hasMember)	[DefinedSet:R-HSA-3299565] TLE tetramer [nucleoplasm]