Reactome | Retinoid cycle disease events

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Retinoid cycle disease events Show undefined attributes

authored	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17
created	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17
crossReference	[DatabaseIdentifier:12020952] Mondo:0005283
dbId	2453864
disease	[Disease:2477157] retinal disease
displayName	Retinoid cycle disease events
edited	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17 [InstanceEdit:9918451] Orlic-Milacic, Marija, 2024-08-15
eventOf	[Pathway:R-HSA-2474795] Diseases associated with visual transduction - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9918449] Defective visual phototransduction due to STRA6 loss of function - Homo sapiens [Pathway:R-HSA-9918442] Defective visual phototransduction due to LRAT loss of function - Homo sapiens [Pathway:R-HSA-9918454] Defective visual phototransduction due to ABCA4 loss of function - Homo sapiens [Pathway:R-HSA-9918443] Defective visual phototransduction due to OPN1SW loss of function - Homo sapiens [Pathway:R-HSA-9918436] Defective visual phototransduction due to OPN1MW loss of function - Homo sapiens [Pathway:R-HSA-9918450] Defective visual phototransduction due to OPN1LW loss of function - Homo sapiens [Pathway:R-HSA-9918440] Defective visual phototransduction due to RDH12 loss of function - Homo sapiens [Pathway:R-HSA-9918438] Defective visual phototransduction due to RDH5 loss of function - Homo sapiens [Pathway:R-HSA-2466712] Biosynthesis of A2E, implicated in retinal degradation - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2019-09-09
literatureReference	[LiteratureReference:2477158] Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents [LiteratureReference:2484842] Retinoids for treatment of retinal diseases [LiteratureReference:2484837] Animal models of retinal disease [LiteratureReference:2484841] Leber congenital amaurosis: genes, proteins and disease mechanisms
maxDepth	3
modified	[InstanceEdit:9984898] Weiser, Joel, 2026-03-12
name	Retinoid cycle disease events
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-03-12
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3006584] Blaner, William S, 2013-01-31 [InstanceEdit:9919312] Matthews, Lisa, 2024-08-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2453864
summation	[Summation:2484838] The gene defects which cause diseases related to the retinoi...
updateTrackers	[UpdateTracker:9784004] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v55:[removeHasEvent, updateContainedRLE] [UpdateTracker:9919486] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v90:[add_removeHasEvent] [UpdateTracker:9777647] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v70:[updateContainedRLE] [UpdateTracker:9778831] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v67:[updateContainedRLE] [UpdateTracker:9787408] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v45:[updateIndirectRLE] [UpdateTracker:9779964] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v64:[updateContainedRLE] [UpdateTracker:9777857] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v68:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9784004] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v55:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9919486] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v90:[add_removeHasEvent]
[UpdateTracker:9777647] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v70:[updateContainedRLE]
[UpdateTracker:9778831] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v67:[updateContainedRLE]
[UpdateTracker:9787408] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v45:[updateIndirectRLE]
[UpdateTracker:9779964] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v64:[updateContainedRLE]
[UpdateTracker:9777857] Update Tracker - [Pathway:2453864] Retinoid cycle disease events - v68:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-2474795] Diseases associated with visual transduction

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