Reactome | Phosphorylation of BTK by p-SYK

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Phosphorylation of BTK by p-SYK Show undefined attributes

authored	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
catalystActivity	[CatalystActivity:2396614] protein tyrosine kinase activity of DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2424489] Garapati, P V, 2012-07-23
dbId	2424484
displayName	Phosphorylation of BTK by p-SYK
edited	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
eventOf	[Pathway:R-HSA-2424491] DAP12 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-2424487] Phosphorylation of PLC-gamma by p-BTK/p-SYK - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2424461] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2424347] Btk is a positive regulator in the TREM-1/DAP12 signaling pathway
maxDepth	1
modified	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
name	Phosphorylation of BTK by p-SYK
orthologousEvent	[Reaction:R-MMU-2424484] Phosphorylation of BTK by p-SYK - Mus musculus [Reaction:R-CFA-2424484] Phosphorylation of BTK by p-SYK - Canis familiaris [Reaction:R-RNO-2424484] Phosphorylation of BTK by p-SYK - Rattus norvegicus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2424457] p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane]
precedingEvent	[Reaction:R-HSA-2424481] Recruitment of VAV and BTK to p-SLP-76 - Homo sapiens [Reaction:R-HSA-2395412] Phosphorylation of SYK - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2428957] Lanier, Lewis L, 2012-08-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2424484
summation	[Summation:2424343] In myeloid cells BTK is phosphorylated on Y551 upon DAP12 ac...

Referrals

(hasEvent)	[Pathway:R-HSA-2424491] DAP12 signaling
(precedingEvent)	[Reaction:R-HSA-2424487] Phosphorylation of PLC-gamma by p-BTK/p-SYK

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