Reactome | Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix

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Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix Show undefined attributes

authored	[InstanceEdit:266384] Geiger, B, Horwitz, R, 2008-05-07 08:30:32
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:216049] Garapati, P V, 2008-03-11 10:16:02
dbId	216050
displayName	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix
edited	[InstanceEdit:216084] Garapati, P V, 2008-03-11 10:20:45
eventOf	[Pathway:R-HSA-216083] Integrin cell surface interactions - Homo sapiens
input	[Polymer:R-HSA-2327729] Fibronectin matrix [extracellular region] [DefinedSet:R-HSA-4205071] Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:215376] VLA-4-fibronectin interaction is required for the terminal differentiation of human bone marrow cells capable of spontaneous and high rate immunoglobulin secretion [LiteratureReference:215314] Effect of the interaction between fibronectin and VLA-4 on the proliferation of human B cells, especially a novel human B-cell line, OPM-3
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix
orthologousEvent	[Reaction:R-CEL-216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - Caenorhabditis elegans [Reaction:R-GGA-216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - Gallus gallus [Reaction:R-XTR-216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - Xenopus tropicalis [Reaction:R-DRE-216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - Danio rerio [Reaction:R-SSC-216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - Sus scrofa [Reaction:R-BTA-216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - Bos taurus [Reaction:R-CFA-216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - Canis familiaris [Reaction:R-RNO-216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - Rattus norvegicus [Reaction:R-MMU-216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - Mus musculus
output	[Complex:R-HSA-216035] Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix [plasma membrane]
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:266386] Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-216050
summation	[Summation:4205074] Several integrins are able to bind fibronectin (FN1). Alpha5...
updateTrackers	[UpdateTracker:9787249] Update Tracker - [Reaction:216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - v46:[add_removeInput, add_removeSummation]

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(updatedInstance)	[UpdateTracker:9787249] Update Tracker - [Reaction:216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - v46:[add_removeInput, add_removeSummation]
(hasEvent)	[Pathway:R-HSA-216083] Integrin cell surface interactions