Reactome | Stimulation of the cell death response by PAK-2p34

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Stimulation of the cell death response by PAK-2p34 Show undefined attributes

authored	[InstanceEdit:211644] Jakobi, R, 2008-02-05 11:04:14
created	[InstanceEdit:211735] Matthews, L, 2008-02-08 01:00:54
dbId	211736
displayName	Stimulation of the cell death response by PAK-2p34
edited	[InstanceEdit:211619] Matthews, L, 2008-02-03 20:50:13 [InstanceEdit:353176] Matthews, L, 2008-06-12 00:23:53
eventOf	[Pathway:R-HSA-75153] Apoptotic execution phase - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-211651] Cleavage of PAK-2 at 212 - Homo sapiens [Reaction:R-HSA-211650] Autophosphorylation of PAK-2p34 in the activation loop - Homo sapiens [Reaction:R-HSA-211712] Proteolytic PAK-2p34 fragment translocates to the nucleus - Homo sapiens [Reaction:R-HSA-211583] Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2011-09-30
literatureReference	[LiteratureReference:211655] Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation [LiteratureReference:211630] Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity [LiteratureReference:211685] Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2 [LiteratureReference:211657] Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Stimulation of the cell death response by PAK-2p34
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:352466] Chang, E, 2008-05-21 00:05:41
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-211736
summation	[Summation:211674] In response to stress signals, the p21-activated protein kin...
updateTrackers	[UpdateTracker:9790393] Update Tracker - [Pathway:211736] Stimulation of the cell death response by PAK-2p34 - v33:[addHasEvent] [UpdateTracker:9789328] Update Tracker - [Pathway:211736] Stimulation of the cell death response by PAK-2p34 - v38:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9790393] Update Tracker - [Pathway:211736] Stimulation of the cell death response by PAK-2p34 - v33:[addHasEvent] [UpdateTracker:9789328] Update Tracker - [Pathway:211736] Stimulation of the cell death response by PAK-2p34 - v38:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-75153] Apoptotic execution phase