Reactome | WWTR1:SMAD stimulates transcription of SMAD7

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WWTR1:SMAD stimulates transcription of SMAD7 Show undefined attributes

authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2106589] Orlic-Milacic, M, 2012-02-10
dbId	2106591
displayName	WWTR1:SMAD stimulates transcription of SMAD7
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens
followingEvent	[Reaction:R-HSA-178208] SMAD7 binds to SMURF2 - Homo sapiens [Reaction:R-HSA-2167917] SMAD7 binds to SMURF1 - Homo sapiens [Reaction:R-HSA-2176416] NEDD4L ubiquitin ligase binds SMAD7 - Homo sapiens [Reaction:R-HSA-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Homo sapiens [Reaction:R-HSA-2186771] RNF111 binds SMAD7 - Homo sapiens [Reaction:R-HSA-9736966] SMAD7 binds SERPINE1 gene promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2106587] SMAD7 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2031354] TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal [LiteratureReference:5251997] Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WWTR1:SMAD stimulates transcription of SMAD7
output	[EntityWithAccessionedSequence:R-HSA-178197] SMAD7 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9736970] WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter - Homo sapiens [Reaction:R-HSA-5252001] ATP1B4 binds SNW1 - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-2106584] Positive gene expression regulation by 'WWTR1:p-2S-SMAD2,3:SMAD4:SMAD7 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5255397] Positive gene expression regulation by 'ATP1B4:SNW1 [nucleoplasm]'
regulationReference	[RegulationReference:9642308] Positive gene expression regulation by 'WWTR1:p-2S-SMAD2,3:SMAD4:SMAD7 gene [nucleoplasm]' TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2106591
summation	[Summation:2106596] Knocking down WWTR1 (TAZ) expression by siRNA treatment inhi...
updateTrackers	[UpdateTracker:9775746] Update Tracker - [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 - v78:[add_removeRegulator] [UpdateTracker:9785313] Update Tracker - [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 - v52:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775746] Update Tracker - [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 - v78:[add_removeRegulator] [UpdateTracker:9785313] Update Tracker - [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 - v52:[addLiteratureReference, addRegulator, modifyText]
(precedingEvent)	[Reaction:R-HSA-178208] SMAD7 binds to SMURF2 [Reaction:R-HSA-2167917] SMAD7 binds to SMURF1 [Reaction:R-HSA-2176416] NEDD4L ubiquitin ligase binds SMAD7 [Reaction:R-HSA-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) [Reaction:R-HSA-9736966] SMAD7 binds SERPINE1 gene promoter [Reaction:R-HSA-2186771] RNF111 binds SMAD7
(hasEvent)	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity

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