Reactome | FGFR4 mutant dimers with enhanced kinase activity:PD173074 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2046361] Rothfels, K, 2012-01-11
crossReference	[DatabaseIdentifier:12020750] Mondo:0005212
dbId	2046360
disease	[Disease:1500689] cancer [Disease:1614291] rhabdomyosarcoma
displayName	FGFR4 mutant dimers with enhanced kinase activity:PD173074 [plasma membrane]
hasComponent	[CandidateSet:R-HSA-2038942] FGFR4 enhanced kinase mutant dimers [plasma membrane] 2 × [ChemicalDrug:R-ALL-2038919] PD173074 [cytosol]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
literatureReference	[LiteratureReference:2038923] Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
maxDepth	4
modified	[InstanceEdit:5675012] Rothfels, Karen, 2015-02-14
name	FGFR4 mutant dimers with enhanced kinase activity:PD173074
producedByEvent	[Reaction:R-HSA-2046363] FGFR4 kinase mutants are inhibited by PD170734 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2046360
updateTrackers	[UpdateTracker:9895714] Update Tracker - [Complex:2046360] FGFR4 mutant dimers with enhanced kinase activity:PD173074 [plasma membrane] - v59:[updateContainedComponent] [UpdateTracker:9891834] Update Tracker - [Complex:2046360] FGFR4 mutant dimers with enhanced kinase activity:PD173074 [plasma membrane] - v52:[removeCompartment]

(updatedInstance)	[UpdateTracker:9895714] Update Tracker - [Complex:2046360] FGFR4 mutant dimers with enhanced kinase activity:PD173074 [plasma membrane] - v59:[updateContainedComponent] [UpdateTracker:9891834] Update Tracker - [Complex:2046360] FGFR4 mutant dimers with enhanced kinase activity:PD173074 [plasma membrane] - v52:[removeCompartment]
(output)	[Reaction:R-HSA-2046363] FGFR4 kinase mutants are inhibited by PD170734

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