Reactome | FGFR3 point mutants with enhanced kinase activity [plasma membrane]

Schema > CandidateSet > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2033476] Dimerization of FGFR3 point mutants with enhanced kinase activity - Homo sapiens
created	[InstanceEdit:2018769] Rothfels, K, 2011-11-24
dbId	2018770
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	FGFR3 point mutants with enhanced kinase activity [plasma membrane]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-1614390] FGFR3 A391E [plasma membrane] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-1614398] FGFR3 G380R [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2018740] FGFR3 G382D [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1614400] FGFR3 K650E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1614402] FGFR3 K650M [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1614406] FGFR3 K650N [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1614410] FGFR3 K650Q [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1614411] FGFR3 K650T [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2018743] FGFR3b G697C [plasma membrane] - Homo sapiens
inDisease	true
modified	[InstanceEdit:2065853] Rothfels, K, 2012-01-24
name	FGFR3 point mutants with enhanced kinase activity
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2018770

(input)	[Reaction:R-HSA-2033476] Dimerization of FGFR3 point mutants with enhanced kinase activity
(diseaseEntity)	[EntityFunctionalStatus:5654492] gain_of_function of FGFR3 point mutants with enhanced kinase activity [plasma membrane]