Reactome | p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]

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p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:196225] protein serine/threonine kinase activity of p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-HSA-195283] Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 - Homo sapiens
created	[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
dbId	195313
displayName	p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
hasComponent	[Complex:R-HSA-3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [EntityWithAccessionedSequence:R-HSA-8942367] p-T41,S45 CTNNB1 [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Mus musculus [Complex:R-RNO-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Rattus norvegicus [Complex:R-CFA-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Canis familiaris [Complex:R-BTA-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Bos taurus [Complex:R-SSC-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Sus scrofa [Complex:R-DRE-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Danio rerio [Complex:R-XTR-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Xenopus tropicalis [Complex:R-GGA-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Gallus gallus [Complex:R-DME-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Drosophila melanogaster [Complex:R-CEL-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Caenorhabditis elegans
maxDepth	5
modified	[InstanceEdit:8943895] Rothfels, Karen, 2016-10-31
name	p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex
producedByEvent	[Reaction:R-HSA-195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-195313
updateTrackers	[UpdateTracker:9871461] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v40:[modifyName, updateContainedComponent] [UpdateTracker:9873528] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v43:[updateContainedComponent] [UpdateTracker:9868006] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v28:[updateContainedComponent] [UpdateTracker:9888668] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v47:[modifyName, updateContainedComponent] [UpdateTracker:9895745] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v59:[add_removeHasComponent, modifyName] [UpdateTracker:9888992] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v48:[add_removeHasComponent, modifyName] [UpdateTracker:9889572] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v49:[modifyName, updateContainedComponent] [UpdateTracker:9871169] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v39:[updateContainedComponent] [UpdateTracker:9878779] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v44:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9871461] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v40:[modifyName, updateContainedComponent] [UpdateTracker:9873528] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v43:[updateContainedComponent] [UpdateTracker:9868006] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v28:[updateContainedComponent] [UpdateTracker:9888668] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v47:[modifyName, updateContainedComponent] [UpdateTracker:9895745] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v59:[add_removeHasComponent, modifyName] [UpdateTracker:9888992] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v48:[add_removeHasComponent, modifyName] [UpdateTracker:9889572] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v49:[modifyName, updateContainedComponent] [UpdateTracker:9871169] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v39:[updateContainedComponent] [UpdateTracker:9878779] Update Tracker - [Complex:195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v44:[updateContainedComponent]
(normalEntity)	[EntityFunctionalStatus:4839620] loss_of_function of pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]
(output)	[Reaction:R-HSA-195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
(input)	[Reaction:R-HSA-195283] Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
(physicalEntity)	[CatalystActivity:196225] protein serine/threonine kinase activity of p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]

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