Reactome | IRAK is activated

Schema > Reaction > Entries

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:193934] protein serine/threonine kinase activity of unknown kinase [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:193693] Jassal, B, 2007-02-23 15:02:35
dbId	193647
displayName	IRAK is activated
edited	[InstanceEdit:350668] Jassal, B, 2008-05-20 12:26:36
eventOf	[Pathway:R-HSA-209543] p75NTR recruits signalling complexes - Homo sapiens
followingEvent	[Reaction:R-HSA-193695] IRAK interacts with TRAF6 - Homo sapiens
inferredFrom	[Reaction:R-RNO-193887] Irak is activated - Rattus norvegicus
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-209570] NGF ligand:p75NTR:IRAK1:MYD88 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRAK is activated
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-209572] NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane]
precedingEvent	[Reaction:R-HSA-193686] p75NTR interacts with IRAK:MYD88 - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:350667] Friedman, WJ, 2008-05-20 12:23:46 [InstanceEdit:351795] Chao, MV, 2008-05-28 09:46:01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193647
summation	[Summation:193920] Upon recruitment to p75NTR, Interleukin-1 receptor-associate...

(hasEvent)	[Pathway:R-HSA-209543] p75NTR recruits signalling complexes
(precedingEvent)	[Reaction:R-HSA-193695] IRAK interacts with TRAF6
(inferredTo)	[Reaction:R-RNO-193887] Irak is activated

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