Reactome | Viral Polymerase Assembly

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Viral Polymerase Assembly Show undefined attributes

authored	[InstanceEdit:193029] Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:192697] Gillespie, ME, 2007-02-07 04:51:41
crossReference	[DatabaseIdentifier:12020763] Mondo:0005812
dbId	192830
disease	[Disease:1660558] influenza
displayName	Viral Polymerase Assembly
eventOf	[Pathway:R-HSA-192905] vRNP Assembly - Homo sapiens
followingEvent	[Reaction:R-HSA-168326] Assembly of an Active Transcription Complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-FLU-188877] PA [nucleoplasm] [EntityWithAccessionedSequence:R-FLU-188843] PB1 [nucleoplasm] [EntityWithAccessionedSequence:R-FLU-188857] PB2 [nucleoplasm]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:192723] Identification of two separate domains in the influenza virus PB1 protein involved in the interaction with the PB2 and PA subunits: a model for the viral RNA polymerase structure [LiteratureReference:192710] Functional analysis of PA binding by influenza a virus PB1: effects on polymerase activity and viral infectivity [LiteratureReference:192676] The three influenza virus polymerase (P) proteins not associated with viral nucleocapsids in the infected cell are in the form of a complex [LiteratureReference:169542] Nuclear location of all three influenza polymerase proteins and a nuclear signal in polymerase PB2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Viral Polymerase Assembly
output	[Complex:R-FLU-192720] Viral Polymerase [nucleoplasm]
precedingEvent	[Reaction:R-HSA-168310] Release of the RNP into the host cell nucleus - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-192952] Positive regulation by 'IPO5 [nucleoplasm]' [PositiveRegulation:R-HSA-192953] Positive regulation by 'HSP90AA1 [cytosol]'
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2007-02-28
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:193030] Squires, B, 2007-02-12 19:39:22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-192830
summation	[Summation:192748] The mature ternary influenza viral polymerase complex consis...

Referrals

(hasEvent)	[Pathway:R-HSA-192905] vRNP Assembly
(precedingEvent)	[Reaction:R-HSA-168326] Assembly of an Active Transcription Complex