Reactome | Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)

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Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) Show undefined attributes

authored	[InstanceEdit:192484] D'Eustachio, P, 2007-02-02 21:43:49
catalystActivity	[CatalystActivity:192461] sterol ester esterase activity of dimerized CEL:bile salt complex [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:192484] D'Eustachio, P, 2007-02-02 21:43:49
crossReference	[DatabaseIdentifier:9966218] RHEA:10101
dbId	192417
displayName	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)
eventOf	[Pathway:R-HSA-192456] Digestion of dietary lipid - Homo sapiens
followingEvent	[Reaction:R-HSA-265443] NPC1L1-mediated cholesterol uptake - Homo sapiens
input	[SimpleEntity:R-ALL-171076] CHEST [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:192471] Studies on the substrate specificity of a carboxyl ester hydrolase from human pancreatic juice. II. Action on cholesterol esters and lipid-soluble vitamin esters.
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)
orthologousEvent	[Reaction:R-CEL-192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - Caenorhabditis elegans [Reaction:R-DME-192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - Drosophila melanogaster [Reaction:R-GGA-192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - Gallus gallus [Reaction:R-XTR-192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - Xenopus tropicalis [Reaction:R-DRE-192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - Danio rerio [Reaction:R-SSC-192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - Sus scrofa [Reaction:R-BTA-192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - Bos taurus [Reaction:R-RNO-192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - Rattus norvegicus [Reaction:R-MMU-192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - Mus musculus
output	[SimpleEntity:R-ALL-171149] CHOL [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-174602] LCFAs [extracellular region]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9971320] D'Eustachio, Peter, 2025-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-192417
summation	[Summation:192426] CEL (bile salt-dependent lipase) catalyzes the hydrolysis of...
updateTrackers	[UpdateTracker:9971915] Update Tracker - [Reaction:192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - v95:[removeOutput] [UpdateTracker:9791922] Update Tracker - [Reaction:192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - v25:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9971915] Update Tracker - [Reaction:192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - v95:[removeOutput] [UpdateTracker:9791922] Update Tracker - [Reaction:192417] Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) - v25:[modifyText]
(precedingEvent)	[Reaction:R-HSA-265443] NPC1L1-mediated cholesterol uptake
(hasEvent)	[Pathway:R-HSA-192456] Digestion of dietary lipid