Reactome | Oligomerization of connexins into connexons

Schema > Pathway > Entries

Oligomerization of connexins into connexons Show undefined attributes

authored	[InstanceEdit:190523] Gilleron, J, Segretain, D, Falk, MM, 2007-01-03 12:23:09
created	[InstanceEdit:190700] Matthews, L, 2007-01-09 12:41:03
dbId	190704
displayName	Oligomerization of connexins into connexons
edited	[InstanceEdit:191950] Matthews, L, 2007-01-26 11:39:00
eventOf	[Pathway:R-HSA-190861] Gap junction assembly - Homo sapiens
figure	[Figure:190453] /figures/gapjunc_Fig3.jpg
followingEvent	[Pathway:R-HSA-190872] Transport of connexons to the plasma membrane - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-190681] Connexin oligomerization in endoplasmic reticulum membrane - Homo sapiens [Reaction:R-HSA-190687] Connexin oligomerization in ER-Golgi-Intermediate Compartment - Homo sapiens [Reaction:R-HSA-190662] Connexin oligomerization in Trans-Golgi Network (TGN) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2011-09-30
literatureReference	[LiteratureReference:190537] Assembly of heteromeric connexons in guinea-pig liver en route to the Golgi apparatus, plasma membrane and gap junctions [LiteratureReference:190615] Cell-free synthesis and assembly of connexins into functional gap junction membrane channels [LiteratureReference:190460] Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER [LiteratureReference:193194] N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26 [LiteratureReference:193186] Post-translational integration and oligomerization of connexin 26 in plasma membranes and evidence of formation of membrane pores: implications for the assembly of gap junctions [LiteratureReference:190709] Specific amino-acid residues in the N-terminus and TM3 implicated in channel function and oligomerization compatibility of connexin43 [LiteratureReference:190680] Synthesis and assembly of connexins in vitro into homomeric and heteromeric functional gap junction hemichannels
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Oligomerization of connexins into connexons
orthologousEvent	[Pathway:R-GGA-190704] Oligomerization of connexins into connexons - Gallus gallus [Pathway:R-XTR-190704] Oligomerization of connexins into connexons - Xenopus tropicalis [Pathway:R-DRE-190704] Oligomerization of connexins into connexons - Danio rerio [Pathway:R-SSC-190704] Oligomerization of connexins into connexons - Sus scrofa [Pathway:R-BTA-190704] Oligomerization of connexins into connexons - Bos taurus [Pathway:R-CFA-190704] Oligomerization of connexins into connexons - Canis familiaris [Pathway:R-RNO-190704] Oligomerization of connexins into connexons - Rattus norvegicus [Pathway:R-MMU-190704] Oligomerization of connexins into connexons - Mus musculus
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-190704
summation	[Summation:190719] The mechanism of connexin assembly into connexons has been w...
updateTrackers	[UpdateTracker:9789899] Update Tracker - [Pathway:190704] Oligomerization of connexins into connexons - v36:[modifyText, updateContainedRLE] [UpdateTracker:9789276] Update Tracker - [Pathway:190704] Oligomerization of connexins into connexons - v38:[addLiteratureReference] [UpdateTracker:9792429] Update Tracker - [Pathway:190704] Oligomerization of connexins into connexons - v21:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9789899] Update Tracker - [Pathway:190704] Oligomerization of connexins into connexons - v36:[modifyText, updateContainedRLE] [UpdateTracker:9789276] Update Tracker - [Pathway:190704] Oligomerization of connexins into connexons - v38:[addLiteratureReference] [UpdateTracker:9792429] Update Tracker - [Pathway:190704] Oligomerization of connexins into connexons - v21:[updateContainedRLE]
(precedingEvent)	[Pathway:R-HSA-190872] Transport of connexons to the plasma membrane
(hasEvent)	[Pathway:R-HSA-190861] Gap junction assembly

Cite Us!