Reactome | I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen

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I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2024013] inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity of MINPP1 [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
crossReference	[DatabaseIdentifier:12667487] RHEA:77144 [DatabaseIdentifier:9966609] RHEA:77144
dbId	1855163
displayName	I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1855231] Synthesis of IPs in the ER lumen - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1855189] I(1,4,5,6)P4 transports from the ER lumen to the nucleus - Homo sapiens
input	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-2024008] I(1,3,4,5,6)P5 [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889863] The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification [LiteratureReference:1889793] Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen
orthologousEvent	[Reaction:R-DDI-1855163] I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen - Dictyostelium discoideum [Reaction:R-DME-1855163] I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen - Drosophila melanogaster [Reaction:R-GGA-1855163] I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen - Gallus gallus [Reaction:R-DRE-1855163] I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen - Danio rerio [Reaction:R-SSC-1855163] I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen - Sus scrofa [Reaction:R-BTA-1855163] I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen - Bos taurus [Reaction:R-CFA-1855163] I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen - Canis familiaris [Reaction:R-RNO-1855163] I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen - Rattus norvegicus [Reaction:R-MMU-1855163] I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen - Mus musculus
output	[SimpleEntity:R-ALL-2024012] I(1,4,5,6)P4 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113551] Pi [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-1855195] I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen - Homo sapiens [Reaction:R-HSA-1855225] IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1855163
summation	[Summation:2024019] In the endoplasmic reticulum (ER) lumen, multiple inositol p...

Referrals

(hasEvent)	[Pathway:R-HSA-1855231] Synthesis of IPs in the ER lumen
(precedingEvent)	[BlackBoxEvent:R-HSA-1855189] I(1,4,5,6)P4 transports from the ER lumen to the nucleus