Reactome | Pro-EGF is cleaved to form mature EGF

Schema > Reaction > Entries

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity	[CatalystActivity:179871] metalloendopeptidase activity of ADAM:Zn2+ [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
dbId	177946
displayName	Pro-EGF is cleaved to form mature EGF
eventOf	[Pathway:R-HSA-177929] Signaling by EGFR - Homo sapiens
followingEvent	[Reaction:R-HSA-177942] EGFR binds EGF ligand - Homo sapiens
inferredFrom	[Reaction:R-MMU-179883] Mouse pro-EGF is cleaved by ADAM sheddases - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-179888] Pro-EGF [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Pro-EGF is cleaved to form mature EGF
output	[EntityWithAccessionedSequence:R-HSA-179863] EGF [extracellular region]
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:193358] Muthuswamy, S, 2007-02-16 20:08:05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-177946
summation	[Summation:179818] Ligands of the epidermal growth factor receptor (EGFR) are ...
updateTrackers	[UpdateTracker:9792081] Update Tracker - [Reaction:177946] Pro-EGF is cleaved to form mature EGF - v24:[modifyText]

(updatedInstance)	[UpdateTracker:9792081] Update Tracker - [Reaction:177946] Pro-EGF is cleaved to form mature EGF - v24:[modifyText]
(hasEvent)	[Pathway:R-HSA-177929] Signaling by EGFR
(precedingEvent)	[Reaction:R-HSA-177942] EGFR binds EGF ligand
(inferredTo)	[Reaction:R-MMU-179883] Mouse pro-EGF is cleaved by ADAM sheddases

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