Reactome | Association of Cyclin A with the APC/C

Schema > Reaction > Entries

Association of Cyclin A with the APC/C Show undefined attributes

authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
dbId	174171
displayName	Association of Cyclin A with the APC/C
edited	[InstanceEdit:176455] Matthews, L, 2006-03-07 23:49:09
eventOf	[Pathway:R-HSA-174184] Cdc20:Phospho-APC/C mediated degradation of Cyclin A - Homo sapiens
followingEvent	[Reaction:R-HSA-174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex - Homo sapiens
input	[Complex:R-HSA-174232] Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] [Complex:R-HSA-141410] MCC:APC/C complex [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:174080] Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex [LiteratureReference:174075] Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Association of Cyclin A with the APC/C
negativePrecedingEvent	[NegativePrecedingEvent:9764139] Futile Cycle: Degradation multiubiquitinated Cyclin A [NegativePrecedingEvent:9764137] Futile Cycle: Degradation of multiubiquitinated Nek2A
orthologousEvent	[Reaction:R-DME-174171] Association of Cyclin A with the APC/C - Drosophila melanogaster [Reaction:R-GGA-174171] Association of Cyclin A with the APC/C - Gallus gallus [Reaction:R-XTR-174171] Association of Cyclin A with the APC/C - Xenopus tropicalis [Reaction:R-DRE-174171] Association of Cyclin A with the APC/C - Danio rerio [Reaction:R-SSC-174171] Association of Cyclin A with the APC/C - Sus scrofa [Reaction:R-BTA-174171] Association of Cyclin A with the APC/C - Bos taurus [Reaction:R-CFA-174171] Association of Cyclin A with the APC/C - Canis familiaris [Reaction:R-RNO-174171] Association of Cyclin A with the APC/C - Rattus norvegicus [Reaction:R-MMU-174171] Association of Cyclin A with the APC/C - Mus musculus
output	[Complex:R-HSA-174140] Cdc2:Cyclin A:MCC:APC/C complex [cytosol]
precedingEvent	[Reaction:R-HSA-141423] Binding of the MCC complex to the APC/C complex - Homo sapiens
releaseDate	2005-04-11
requiredInputComponent	[EntityWithAccessionedSequence:R-HSA-141412] CDC20 [cytosol] - Homo sapiens [CandidateSet:R-HSA-170089] CCNA [cytosol] - Homo sapiens
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174171
summation	[Summation:176895] Cyclin A is believed to be recognized by the APC/C:Cdc20 com...

Referrals

(hasEvent)	[Pathway:R-HSA-174184] Cdc20:Phospho-APC/C mediated degradation of Cyclin A
(precedingEvent)	[Reaction:R-HSA-174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex