Reactome | TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane]

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TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] Show undefined attributes

catalystActivities	[CatalystActivity:171178] transmembrane receptor protein serine/threonine kinase activity of TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane]
compartment	[Compartment:171062] early endosome membrane
consumedByEvent	[Reaction:R-HSA-170868] Activated type I receptor phosphorylates SMAD2/3 directly - Homo sapiens
created	[InstanceEdit:171265] Jassal, B, 2006-02-02 14:01:29
dbId	171266
displayName	TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane]
hasComponent	[Complex:R-HSA-170852] Dimeric TGFB1 [extracellular region] [Complex:R-HSA-170863] p-TGFBR1 [plasma membrane] [DefinedSet:R-HSA-171172] SMAD2,3 [cytosol] [Complex:R-HSA-170866] TGFBR2 homodimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-206180] ZFYVE9-1 [early endosome membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
inferredTo	[Complex:R-MMU-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - Mus musculus [Complex:R-RNO-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - Rattus norvegicus [Complex:R-CFA-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - Canis familiaris [Complex:R-BTA-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - Bos taurus [Complex:R-SSC-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - Sus scrofa [Complex:R-DRE-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - Danio rerio [Complex:R-XTR-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - Xenopus tropicalis [Complex:R-GGA-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - Gallus gallus [Complex:R-DME-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - Drosophila melanogaster [Complex:R-CEL-171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - Caenorhabditis elegans
maxDepth	3
modified	[InstanceEdit:3656493] Orlic-Milacic, M, 2013-06-05
name	TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 TGFB1:p-TGFBR:SARA:SMAD2/3 TGFB1:TGFBR2:p-5S-T185-TGFBR1:SARA:SMAD2/3 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:R-SMAD complex
producedByEvent	[Reaction:R-HSA-170835] An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-171266
updateTrackers	[UpdateTracker:9902591] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v78:[updateContainedComponent] [UpdateTracker:9888033] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v46:[addName] [UpdateTracker:9871703] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v41:[updateContainedComponent] [UpdateTracker:9876548] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v44:[add_removeHasComponent, updateContainedComponent] [UpdateTracker:9868331] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v30:[updateContainedComponent] [UpdateTracker:9870535] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v38:[addName, updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9902591] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v78:[updateContainedComponent] [UpdateTracker:9888033] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v46:[addName] [UpdateTracker:9871703] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v41:[updateContainedComponent] [UpdateTracker:9876548] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v44:[add_removeHasComponent, updateContainedComponent] [UpdateTracker:9868331] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v30:[updateContainedComponent] [UpdateTracker:9870535] Update Tracker - [Complex:171266] TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] - v38:[addName, updateContainedComponent]
(normalEntity)	[EntityFunctionalStatus:3304395] loss_of_function of TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 Phosphorylation Motif Mutants [early endosome membrane]
(output)	[Reaction:R-HSA-170835] An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
(input)	[Reaction:R-HSA-170868] Activated type I receptor phosphorylates SMAD2/3 directly
(physicalEntity)	[CatalystActivity:171178] transmembrane receptor protein serine/threonine kinase activity of TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane]

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