Reactome | C3G stimulates nucleotide exchange on Rap1

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C3G stimulates nucleotide exchange on Rap1 Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:169894] guanyl-nucleotide exchange factor activity of Active TrkA receptor:Phospho-ARMS:Crk:C3G complex [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:169892] Jassal, B, 2005-12-16 14:06:36
dbId	169904
displayName	C3G stimulates nucleotide exchange on Rap1
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
eventOf	[Pathway:R-HSA-170984] ARMS-mediated activation - Homo sapiens
followingEvent	[Reaction:R-HSA-169901] Rap1-GTP complex binds BRAF complex - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-169860] Rap1-GDP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182016] Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	C3G stimulates nucleotide exchange on Rap1
orthologousEvent	[Reaction:R-DRE-169904] C3G stimulates nucleotide exchange on Rap1 - Danio rerio [Reaction:R-GGA-169904] C3G stimulates nucleotide exchange on Rap1 - Gallus gallus [Reaction:R-SSC-169904] C3G stimulates nucleotide exchange on Rap1 - Sus scrofa [Reaction:R-BTA-169904] C3G stimulates nucleotide exchange on Rap1 - Bos taurus [Reaction:R-CFA-169904] C3G stimulates nucleotide exchange on Rap1 - Canis familiaris [Reaction:R-RNO-169904] C3G stimulates nucleotide exchange on Rap1 - Rattus norvegicus [Reaction:R-MMU-169904] C3G stimulates nucleotide exchange on Rap1 - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-169866] Rap1-GTP [cytosol]
precedingEvent	[Reaction:R-HSA-169895] Crk's SH3 domain engages C3G - Homo sapiens
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-169904
summation	[Summation:187780] Rap1 is a small G protein, necessary for prolonged ERK activ...

Referrals

(precedingEvent)	[Reaction:R-HSA-169901] Rap1-GTP complex binds BRAF complex
(hasEvent)	[Pathway:R-HSA-170984] ARMS-mediated activation

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