Reactome | vRNP Export through the nuclear pore

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vRNP Export through the nuclear pore Show undefined attributes

category	dissociation
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:168887] 2007-04-16 22:35:07
crossReference	[DatabaseIdentifier:12020763] Mondo:0005812
dbId	168880
disease	[Disease:1660558] influenza
displayName	vRNP Export through the nuclear pore
eventOf	[Pathway:R-HSA-168333] NEP/NS2 Interacts with the Cellular Export Machinery - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2454643] intracellular transport of virus
input	[Complex:R-HSA-180738] RAN:GTP [nucleoplasm] [Complex:R-HSA-192667] vRNP Export Complex [nucleoplasm]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:195606] Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade [LiteratureReference:195621] Nuclear export of influenza virus ribonucleoproteins: identification of an export intermediate at the nuclear periphery [LiteratureReference:195611] Inhibition of nuclear export of ribonucleoprotein complexes of influenza virus by leptomycin B [LiteratureReference:195610] A small percentage of influenza virus M1 protein contains zinc but zinc does not influence in vitro M1-RNA interaction [LiteratureReference:192782] Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes [LiteratureReference:167644] The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP [LiteratureReference:195619] A role for the basic patch and the C terminus of RanGTP in regulating the dynamic interactions with importin beta, CRM1 and RanBP1 [LiteratureReference:195608] Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor [LiteratureReference:166936] Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex [LiteratureReference:195605] Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	vRNP Export through the nuclear pore
output	[Complex:R-HSA-165538] Crm1:Ran GTPase:GDP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-FLU-192768] vRNP:M1:NEP:NP [cytosol]
precedingEvent	[Reaction:R-HSA-168857] Binding of vRNP:M1:NEP complex to CRM1 export receptor - Homo sapiens
regulatedBy	[Requirement:R-HSA-192711] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]'
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168880
summation	[Summation:179384] Viral RNP, bound by M1 and NEP/NS2 interacting with CRM1, ar...
updateTrackers	[UpdateTracker:9792467] Update Tracker - [Reaction:168880] vRNP Export through the nuclear pore - v20:[addInput, addOutput, addRegulator, modifyText] [UpdateTracker:9778986] Update Tracker - [Reaction:168880] vRNP Export through the nuclear pore - v66:[add_removeInput] [UpdateTracker:9792456] Update Tracker - [Reaction:168880] vRNP Export through the nuclear pore - v21:[modifyText] [UpdateTracker:9784271] Update Tracker - [Reaction:168880] vRNP Export through the nuclear pore - v54:[addLiteratureReference]

Referrals

(updatedInstance)

[UpdateTracker:9792467] Update Tracker - [Reaction:168880] vRNP Export through the nuclear pore - v20:[addInput, addOutput, addRegulator, modifyText]
[UpdateTracker:9778986] Update Tracker - [Reaction:168880] vRNP Export through the nuclear pore - v66:[add_removeInput]
[UpdateTracker:9792456] Update Tracker - [Reaction:168880] vRNP Export through the nuclear pore - v21:[modifyText]
[UpdateTracker:9784271] Update Tracker - [Reaction:168880] vRNP Export through the nuclear pore - v54:[addLiteratureReference]

(hasEvent)

[Pathway:R-HSA-168333] NEP/NS2 Interacts with the Cellular Export Machinery

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