Reactome | Activated NOD oligomer recruites RIP2 (RICK)

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Activated NOD oligomer recruites RIP2 (RICK) Show undefined attributes

authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:168401] Gillespie, ME, 2005-11-17 05:47:48
dbId	168405
displayName	Activated NOD oligomer recruites RIP2 (RICK)
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
eventOf	[Pathway:R-HSA-168638] NOD1/2 Signaling Pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-741395] CARD9 binds RIP2 (and NOD2) - Homo sapiens [Reaction:R-HSA-622415] RIP2 binds NEMO - Homo sapiens [Reaction:R-HSA-688137] RIP2 is K63 polyubiquitinated - Homo sapiens
input	[DefinedSet:R-HSA-708346] PAMP:NOD oligomer [cytosol] 6 × [EntityWithAccessionedSequence:R-HSA-168402] RIPK2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:622339] Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB [LiteratureReference:622346] Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB [LiteratureReference:168678] Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Activated NOD oligomer recruites RIP2 (RICK)
orthologousEvent	[Reaction:R-DDI-168405] Activated NOD oligomer recruites RIP2 (RICK) - Dictyostelium discoideum [Reaction:R-XTR-168405] Activated NOD oligomer recruites RIP2 (RICK) - Xenopus tropicalis [Reaction:R-DRE-168405] Activated NOD oligomer recruites RIP2 (RICK) - Danio rerio [Reaction:R-BTA-168405] Activated NOD oligomer recruites RIP2 (RICK) - Bos taurus [Reaction:R-CFA-168405] Activated NOD oligomer recruites RIP2 (RICK) - Canis familiaris [Reaction:R-RNO-168405] Activated NOD oligomer recruites RIP2 (RICK) - Rattus norvegicus [Reaction:R-MMU-168405] Activated NOD oligomer recruites RIP2 (RICK) - Mus musculus
output	[Complex:R-HSA-168409] PAMP:NOD oligomer:RIP2 [cytosol]
precedingEvent	[Reaction:R-HSA-622310] Activated NOD1 oligomerizes - Homo sapiens [Reaction:R-HSA-708349] Activated NOD2 oligomerizes - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168405
summation	[Summation:622419] NOD1 and NOD2 (NOD) interact with the inflammatory kinase RI...

Referrals

(hasEvent)	[Pathway:R-HSA-168638] NOD1/2 Signaling Pathway
(precedingEvent)	[Reaction:R-HSA-741395] CARD9 binds RIP2 (and NOD2) [Reaction:R-HSA-622415] RIP2 binds NEMO [Reaction:R-HSA-688137] RIP2 is K63 polyubiquitinated