Reactome | HGSNAT oligomer acetylates Heparan sulfate chain(3)

Schema > Reaction > Entries

HGSNAT oligomer acetylates Heparan sulfate chain(3) Show undefined attributes

authored	[InstanceEdit:1678699] Jassal, B, 2011-10-19
catalystActivity	[CatalystActivity:1678732] heparan-alpha-glucosaminide N-acetyltransferase activity of HGSNAT oligomer [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane [Compartment:70101] cytosol [Compartment:161320] lysosomal lumen
created	[InstanceEdit:1678699] Jassal, B, 2011-10-19
crossReference	[DatabaseIdentifier:9941012] RHEA:15126
dbId	1678660
deleted	[Deleted:9611859] Deletion of instance: 2263501
diseaseReaction	[FailedReaction:R-HSA-9036056] Defective HGSNAT does not acetylate Heparan sulfate chain(3) - Homo sapiens
displayName	HGSNAT oligomer acetylates Heparan sulfate chain(3)
edited	[InstanceEdit:1678699] Jassal, B, 2011-10-19
eventOf	[Pathway:R-HSA-2024096] HS-GAG degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-1678742] NAGLU hydrolyses Heparan sulfate chain(4) - Homo sapiens
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-2090040] GlcN-IdoA2S-GlcNS3S- group [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1678735] Analysis of the biogenesis of heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIIC [LiteratureReference:1678726] Identification of the gene encoding the enzyme deficient in mucopolysaccharidosis IIIC (Sanfilippo disease type C) [LiteratureReference:1678723] Mutations in TMEM76* cause mucopolysaccharidosis IIIC (Sanfilippo C syndrome)
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	HGSNAT oligomer acetylates Heparan sulfate chain(3)
orthologousEvent	[Reaction:R-BTA-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Bos taurus [Reaction:R-DDI-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Dictyostelium discoideum [Reaction:R-DME-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Drosophila melanogaster [Reaction:R-GGA-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Gallus gallus [Reaction:R-XTR-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Xenopus tropicalis [Reaction:R-DRE-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Danio rerio [Reaction:R-SSC-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Sus scrofa [Reaction:R-CFA-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Canis familiaris [Reaction:R-RNO-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Rattus norvegicus [Reaction:R-MMU-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Mus musculus
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-2090069] GlcNAc-IdoA2S-GlcNS3S- group [lysosomal lumen] [SimpleEntity:R-ALL-428040] H+ [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1678708] SGSH hydrolyses Heparan sulfate chain(2) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1678660
summation	[Summation:1678722] Heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT) ace...
updateTrackers	[UpdateTracker:9953700] Update Tracker - [Reaction:1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - v93:[removeOutput] [UpdateTracker:9788434] Update Tracker - [Reaction:1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - v42:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9953700] Update Tracker - [Reaction:1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - v93:[removeOutput] [UpdateTracker:9788434] Update Tracker - [Reaction:1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - v42:[modifyText]
(replacementInstances)	[Deleted:9611859] Deletion of instance: 2263501
(normalReaction)	[FailedReaction:R-HSA-9036056] Defective HGSNAT does not acetylate Heparan sulfate chain(3)
(hasEvent)	[Pathway:R-HSA-2024096] HS-GAG degradation
(precedingEvent)	[Reaction:R-HSA-1678742] NAGLU hydrolyses Heparan sulfate chain(4)

Cite Us!