Reactome | Phosphorylated HSL dimer translocates from the cytosol to the lipid particle

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Phosphorylated HSL dimer translocates from the cytosol to the lipid particle Show undefined attributes

authored	[InstanceEdit:163566] D'Eustachio, P, 2005-05-02 18:38:43
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:13977] lipid droplet
created	[InstanceEdit:163566] D'Eustachio, P, 2005-05-02 18:38:43
dbId	163554
displayName	Phosphorylated HSL dimer translocates from the cytosol to the lipid particle
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-163560] Triglyceride catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-163549] phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:3446241] protein localization to lipid droplet
inferredFrom	[Reaction:R-RNO-163597] Phosphorylated HSL dimer translocates from the cytosol to the lipid particle - Rattus norvegicus
input	[Complex:R-HSA-163513] phosphorylated HSL dimer [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:163569] Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes [LiteratureReference:163555] Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation [LiteratureReference:163593] Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes [LiteratureReference:9961062] Molecular determinants for the association of human hormone-sensitive lipase with lipid droplets
maxDepth	1
modified	[InstanceEdit:9961065] D'Eustachio, Peter, 2025-07-18
name	Phosphorylated HSL dimer translocates from the cytosol to the lipid particle
output	[Complex:R-HSA-163435] phosphorylated HSL dimer [lipid droplet]
precedingEvent	[Reaction:R-HSA-163602] 2 phosphorylated HSL monomers -> phosphorylated HSL dimer - Homo sapiens [Reaction:R-HSA-163418] perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-163554
summation	[Summation:163481] In primary adipocytes from young rats and in adipocytes deri...
updateTrackers	[UpdateTracker:9964669] Update Tracker - [BlackBoxEvent:163554] Phosphorylated HSL dimer translocates from the cytosol to the lipid particle - v94:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9964669] Update Tracker - [BlackBoxEvent:163554] Phosphorylated HSL dimer translocates from the cytosol to the lipid particle - v94:[modifyText, removeLiteratureReference]
(precedingEvent)	[Reaction:R-HSA-163549] phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex
(hasEvent)	[Pathway:R-HSA-163560] Triglyceride catabolism
(inferredTo)	[Reaction:R-RNO-163597] Phosphorylated HSL dimer translocates from the cytosol to the lipid particle

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