Reactome | GALC hydrolyzes GalCer

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GALC hydrolyzes GalCer Show undefined attributes

authored	[InstanceEdit:1606569] Jassal, B, 2011-09-23
catalystActivity	[CatalystActivity:1606568] galactosylceramidase activity of GALC [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:1606569] Jassal, B, 2011-09-23
dbId	1606564
displayName	GALC hydrolyzes GalCer
edited	[InstanceEdit:1606569] Jassal, B, 2011-09-23
eventOf	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-1606602] ASAH1 hydrolyzes ceramide - Homo sapiens
input	[SimpleEntity:R-ALL-1606573] GalCer [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1606576] Purification and characterization of galactocerebrosidase from human lymphocytes [LiteratureReference:1606571] Molecular genetics of Krabbe disease (globoid cell leukodystrophy): diagnostic and clinical implications [LiteratureReference:9841138] Cloning and expression of cDNA encoding human galactocerebrosidase, the enzyme deficient in globoid cell leukodystrophy [LiteratureReference:9841123] Galactocerebrosidase from human urine: purification and partial characterization [LiteratureReference:9841127] Saposin A: second cerebrosidase activator protein [LiteratureReference:9841125] A mutation in the saposin A coding region of the prosaposin gene in an infant presenting as Krabbe disease: first report of saposin A deficiency in humans
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GALC hydrolyzes GalCer
orthologousEvent	[Reaction:R-CEL-1606564] GALC hydrolyzes GalCer - Caenorhabditis elegans [Reaction:R-GGA-1606564] GALC hydrolyzes GalCer - Gallus gallus [Reaction:R-DRE-1606564] GALC hydrolyzes GalCer - Danio rerio [Reaction:R-SSC-1606564] GALC hydrolyzes GalCer - Sus scrofa [Reaction:R-BTA-1606564] GALC hydrolyzes GalCer - Bos taurus [Reaction:R-CFA-1606564] GALC hydrolyzes GalCer - Canis familiaris [Reaction:R-RNO-1606564] GALC hydrolyzes GalCer - Rattus norvegicus [Reaction:R-MMU-1606564] GALC hydrolyzes GalCer - Mus musculus
output	[SimpleEntity:R-ALL-1605673] CERA [lysosomal lumen] [SimpleEntity:R-ALL-1605745] Glc [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1606807] ARSA removes sulfate from PSAP(195-273):Sulfatide - Homo sapiens [Reaction:R-HSA-9841189] GLA hydrolyzes PSAP(195-273):Gal2Cer:PE - Homo sapiens [BlackBoxEvent:R-HSA-9840334] PSAP is cleaved - Homo sapiens
regulatedBy	[Requirement:9841129] Requirement by 'PSAP(60-142) [lysosomal lumen]'
regulationReference	[RegulationReference:9841135] Requirement by 'PSAP(60-142) [lysosomal lumen]' A mutation in the saposin A coding region of the prosaposin gene in an infant presenting as Krabbe disease: first report of saposin A deficiency in humans
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31 [InstanceEdit:9842059] D'Eustachio, Peter, 2023-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1606564
summation	[Summation:1606566] Galactocerebrosidase (GALC) hydrolyses the galactosyl moiety...
updateTrackers	[UpdateTracker:9842245] Update Tracker - [Reaction:1606564] GALC hydrolyzes GalCer - v86:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9842245] Update Tracker - [Reaction:1606564] GALC hydrolyzes GalCer - v86:[addLiteratureReference, addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism
(precedingEvent)	[Reaction:R-HSA-1606602] ASAH1 hydrolyzes ceramide

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