Reactome | Furin cleaves pro-factor VII to factor VII

Schema > Reaction > Entries

Furin cleaves pro-factor VII to factor VII Show undefined attributes

catalystActivity	[CatalystActivity:156993] serine-type endopeptidase activity of FURIN [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:159817] D'Eustachio, P, 2005-03-17 16:24:57
dbId	159868
displayName	Furin cleaves pro-factor VII to factor VII
eventOf	[Pathway:R-HSA-159782] Removal of aminoterminal propeptides from gamma-carboxylated proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-159767] pro-factor VII [Golgi lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6807230] PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Furin cleaves pro-factor VII to factor VII pro-factor VII -> factor VII + factor VII propeptide
orthologousEvent	[Reaction:R-GGA-159868] Furin cleaves pro-factor VII to factor VII - Gallus gallus [Reaction:R-XTR-159868] Furin cleaves pro-factor VII to factor VII - Xenopus tropicalis [Reaction:R-DRE-159868] Furin cleaves pro-factor VII to factor VII - Danio rerio [Reaction:R-SSC-159868] Furin cleaves pro-factor VII to factor VII - Sus scrofa [Reaction:R-BTA-159868] Furin cleaves pro-factor VII to factor VII - Bos taurus [Reaction:R-CFA-159868] Furin cleaves pro-factor VII to factor VII - Canis familiaris [Reaction:R-RNO-159868] Furin cleaves pro-factor VII to factor VII - Rattus norvegicus [Reaction:R-MMU-159868] Furin cleaves pro-factor VII to factor VII - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-159808] factor VII [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-159847] factor VII propeptide [Golgi lumen]
precedingEvent	[BlackBoxEvent:R-HSA-159783] Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-159868
summation	[Summation:179104] Furin, associated with the Golgi membrane, cleaves pro-facto...
updateTrackers	[UpdateTracker:9783845] Update Tracker - [Reaction:159868] Furin cleaves pro-factor VII to factor VII - v55:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783845] Update Tracker - [Reaction:159868] Furin cleaves pro-factor VII to factor VII - v55:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-159782] Removal of aminoterminal propeptides from gamma-carboxylated proteins