Reactome | Furin cleaves pro-protein S to protein S

Schema > Reaction > Entries

Furin cleaves pro-protein S to protein S Show undefined attributes

catalystActivity	[CatalystActivity:156993] serine-type endopeptidase activity of FURIN [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:159817] D'Eustachio, P, 2005-03-17 16:24:57
dbId	159773
displayName	Furin cleaves pro-protein S to protein S
eventOf	[Pathway:R-HSA-159782] Removal of aminoterminal propeptides from gamma-carboxylated proteins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-159850] 11xCbxE-PROS1(25-676) [Golgi membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6807230] PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Furin cleaves pro-protein S to protein S pro-protein S -> protein S + protein S propeptide
orthologousEvent	[Reaction:R-GGA-159773] Furin cleaves pro-protein S to protein S - Gallus gallus [Reaction:R-XTR-159773] Furin cleaves pro-protein S to protein S - Xenopus tropicalis [Reaction:R-DRE-159773] Furin cleaves pro-protein S to protein S - Danio rerio [Reaction:R-SSC-159773] Furin cleaves pro-protein S to protein S - Sus scrofa [Reaction:R-BTA-159773] Furin cleaves pro-protein S to protein S - Bos taurus [Reaction:R-CFA-159773] Furin cleaves pro-protein S to protein S - Canis familiaris [Reaction:R-RNO-159773] Furin cleaves pro-protein S to protein S - Rattus norvegicus [Reaction:R-MMU-159773] Furin cleaves pro-protein S to protein S - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-159865] 11xCbxE-PROS1 [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-159792] PROS1(25-41) [Golgi lumen]
precedingEvent	[BlackBoxEvent:R-HSA-159729] Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-159773
summation	[Summation:179114] Furin, associated with the Golgi membrane, cleaves pro-prote...
updateTrackers	[UpdateTracker:9783811] Update Tracker - [Reaction:159773] Furin cleaves pro-protein S to protein S - v55:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783811] Update Tracker - [Reaction:159773] Furin cleaves pro-protein S to protein S - v55:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-159782] Removal of aminoterminal propeptides from gamma-carboxylated proteins