Reactome | The acetyl group from acetyl-CoA is transferred to NAT2

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The acetyl group from acetyl-CoA is transferred to NAT2 Show undefined attributes

authored	[InstanceEdit:158834] Jassal, B, 2005-02-09 10:26:12
catalystActivity	[CatalystActivity:9954139] protein-cysteine S-acyltransferase activity of NAT2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:158834] Jassal, B, 2005-02-09 10:26:12
dbId	158832
displayName	The acetyl group from acetyl-CoA is transferred to NAT2
eventOf	[Pathway:R-HSA-156582] Acetylation - Homo sapiens
followingEvent	[Reaction:R-HSA-174967] NAT2 acetylation - Homo sapiens
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [EntityWithAccessionedSequence:R-HSA-158692] NAT2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:158835] Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2.
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	The acetyl group from acetyl-CoA is transferred to NAT2
orthologousEvent	[Reaction:R-GGA-158832] The acetyl group from acetyl-CoA is transferred to NAT2 - Gallus gallus [Reaction:R-DRE-158832] The acetyl group from acetyl-CoA is transferred to NAT2 - Danio rerio [Reaction:R-SSC-158832] The acetyl group from acetyl-CoA is transferred to NAT2 - Sus scrofa [Reaction:R-BTA-158832] The acetyl group from acetyl-CoA is transferred to NAT2 - Bos taurus [Reaction:R-RNO-158832] The acetyl group from acetyl-CoA is transferred to NAT2 - Rattus norvegicus [Reaction:R-MMU-158832] The acetyl group from acetyl-CoA is transferred to NAT2 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-158833] AcC-NAT2 [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[Reaction:R-HSA-174967] NAT2 acetylation - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54 [InstanceEdit:9963235] Hill, David P, 2025-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-158832
summation	[Summation:158838] N-acetylation occurs in two sequential steps via a ping-p...
updateTrackers	[UpdateTracker:9964788] Update Tracker - [Reaction:158832] The acetyl group from acetyl-CoA is transferred to NAT2 - v94:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9964788] Update Tracker - [Reaction:158832] The acetyl group from acetyl-CoA is transferred to NAT2 - v94:[removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-156582] Acetylation
(precedingEvent)	[Reaction:R-HSA-174967] NAT2 acetylation

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