Reactome | crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin

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crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin Show undefined attributes

authored	[InstanceEdit:158778] D'Eustachio, P, 2005-02-08 21:36:34
catalystActivity	[CatalystActivity:158768] serine-type endopeptidase activity of fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:158778] D'Eustachio, P, 2005-02-08 21:36:34
dbId	158750
displayName	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-75205] Dissolution of Fibrin Clot - Homo sapiens
followingEvent	[Reaction:R-HSA-158766] fibrin multimer, crosslinked -> fibrin digestion products (plasmin) - Homo sapiens [Reaction:R-HSA-158747] crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) - Homo sapiens [Reaction:R-HSA-158893] alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin - Homo sapiens
input	[Complex:R-HSA-158777] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:158755] Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin. [LiteratureReference:158752] The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site [LiteratureReference:5333754] The crystal structure of a complex of p11 with the annexin II N-terminal peptide [LiteratureReference:5333700] Annexin A2 system in human biology: cell surface and beyond [LiteratureReference:5333724] The annexin A2/S100A10 system in health and disease: emerging paradigms
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
orthologousEvent	[Reaction:R-GGA-158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - Gallus gallus [Reaction:R-XTR-158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - Xenopus tropicalis [Reaction:R-DRE-158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - Danio rerio [Reaction:R-SSC-158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - Sus scrofa [Reaction:R-BTA-158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - Bos taurus [Reaction:R-CFA-158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - Canis familiaris [Reaction:R-RNO-158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - Rattus norvegicus [Reaction:R-MMU-158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - Mus musculus
output	[Complex:R-HSA-158764] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] [Complex:R-HSA-158770] Plasmin [extracellular region]
precedingEvent	[Reaction:R-HSA-158784] crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5336140] Positive regulation by 'ANXA2:S100A10 tetramer [external side of plasma membrane]'
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5674206] Jassal, Bijay, 2015-02-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-158750
summation	[Summation:158749] Plasminogen bound to fibrin is cleaved and activated by tiss...
updateTrackers	[UpdateTracker:9786737] Update Tracker - [Reaction:158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - v48:[addLiteratureReference, modifyText] [UpdateTracker:9786492] Update Tracker - [Reaction:158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - v49:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9786737] Update Tracker - [Reaction:158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - v48:[addLiteratureReference, modifyText] [UpdateTracker:9786492] Update Tracker - [Reaction:158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - v49:[addRegulator]
(hasEvent)	[Pathway:R-HSA-75205] Dissolution of Fibrin Clot
(precedingEvent)	[Reaction:R-HSA-158893] alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin [Reaction:R-HSA-158766] fibrin multimer, crosslinked -> fibrin digestion products (plasmin) [Reaction:R-HSA-158747] crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)

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