Reactome | NOTCH3 binds JAG2

Schema > Reaction > Entries

authored	[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
dbId	157124
deleted	[Deleted:9027574] Deletion of instance: 157644
displayName	NOTCH3 binds JAG2
edited	[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
eventOf	[Pathway:R-HSA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-9013069] Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20089] Notch signaling pathway
inferredFrom	[Reaction:R-MMU-9013059] Notch3 binds Jag2 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-157120] JAG2 [plasma membrane] [Complex:R-HSA-157048] NOTCH3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH3 binds JAG2
output	[Complex:R-HSA-157066] JAG2:NOTCH3 [plasma membrane]
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9027525] Haw, Robin, 2017-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-157124
summation	[Summation:9013060] Based on a study with mouse NOTCH3 and presumably mouse JAG2...

(replacementInstances)	[Deleted:9027574] Deletion of instance: 157644
(hasEvent)	[Pathway:R-HSA-9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus
(precedingEvent)	[Reaction:R-HSA-9013069] Ubiquitination of DLL/JAG ligands upon binding to NOTCH3
(inferredTo)	[Reaction:R-MMU-9013059] Notch3 binds Jag2

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