Reactome | ERBB4 binds WWP1/ITCH ubiquitin ligases

Schema > Reaction > Entries

ERBB4 binds WWP1/ITCH ubiquitin ligases Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9638819] Stern, David F, 2019-02-21
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1253298] Orlic-Milacic, Marija, 2011-04-27
dbId	1253300
displayName	ERBB4 binds WWP1/ITCH ubiquitin ligases
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:9638824] Orlic-Milacic, Marija, 2019-03-05
eventOf	[Pathway:R-HSA-1253288] Downregulation of ERBB4 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-1253282] ERBB4 ubiquitination by WWP1/ITCH - Homo sapiens
input	[DefinedSet:R-HSA-1253281] ERBB4/ERBB4m80/ERBB4s80 [plasma membrane] [DefinedSet:R-HSA-1253275] WWP1/ITCH [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1253295] The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation [LiteratureReference:1253272] The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	ERBB4 binds WWP1/ITCH ubiquitin ligases
orthologousEvent	[Reaction:R-CFA-1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - Canis familiaris [Reaction:R-CEL-1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - Caenorhabditis elegans [Reaction:R-DME-1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - Drosophila melanogaster [Reaction:R-GGA-1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - Gallus gallus [Reaction:R-XTR-1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - Xenopus tropicalis [Reaction:R-DRE-1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - Danio rerio [Reaction:R-SSC-1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - Sus scrofa [Reaction:R-BTA-1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - Bos taurus [Reaction:R-RNO-1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - Rattus norvegicus [Reaction:R-MMU-1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - Mus musculus
output	[Complex:R-HSA-1253284] ERBB4/m80/s80:WWP1/ITCH [plasma membrane]
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1979910] Harris, RC, 2011-11-11 [InstanceEdit:1979909] Zeng, F, 2011-11-11 [InstanceEdit:2104982] Earp HS, 3rd, 2012-02-20 [InstanceEdit:2104979] Misior, AM, 2012-02-20
revised	[InstanceEdit:2104982] Earp HS, 3rd, 2012-02-20 [InstanceEdit:2104979] Misior, AM, 2012-02-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1253300
summation	[Summation:1253287] Intact ERBB4 isoforms and their membrane bound and cytosolic...
updateTrackers	[UpdateTracker:9788727] Update Tracker - [Reaction:1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - v40:[modifyText] [UpdateTracker:9779473] Update Tracker - [Reaction:1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - v65:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788727] Update Tracker - [Reaction:1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - v40:[modifyText] [UpdateTracker:9779473] Update Tracker - [Reaction:1253300] ERBB4 binds WWP1/ITCH ubiquitin ligases - v65:[modifyText]
(hasEvent)	[Pathway:R-HSA-1253288] Downregulation of ERBB4 signaling
(precedingEvent)	[Reaction:R-HSA-1253282] ERBB4 ubiquitination by WWP1/ITCH

Cite Us!