Reactome | NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane]

catalystActivities	[CatalystActivity:1181151] protein serine/threonine kinase activity of NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-1181156] Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL - Homo sapiens
created	[InstanceEdit:1225868] May, B, 2011-03-03
dbId	1225875
displayName	NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane]
hasComponent	[Complex:R-HSA-1181132] ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] [DefinedSet:R-HSA-1226027] NODAL dimer, NODAL:GDF1 [extracellular region]
inDisease	false
includedLocation	[Compartment:984] extracellular region
inferredFrom	[Complex:R-NUL-1181338] Nodal:Nodal Receptor (human-mouse chimera) [plasma membrane] - Homo sapiens
isChimeric	false
maxDepth	4
modified	[InstanceEdit:6788950] May, Bruce, 2015-07-28
name	NODAL:ACVR1B:ACVR2A,B:EGF-CFC
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1225875
updateTrackers	[UpdateTracker:9874265] Update Tracker - [Complex:1225875] NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] - v43:[updateContainedComponent] [UpdateTracker:9872480] Update Tracker - [Complex:1225875] NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] - v41:[removeCompartment] [UpdateTracker:9888827] Update Tracker - [Complex:1225875] NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] - v48:[updateContainedComponent] [UpdateTracker:9893012] Update Tracker - [Complex:1225875] NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] - v54:[add_removeHasComponent, modifyName, updateContainedComponent] [UpdateTracker:9894987] Update Tracker - [Complex:1225875] NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] - v58:[updateContainedComponent]

NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] Show undefined attributes

Referrals

(updatedInstance)	[UpdateTracker:9874265] Update Tracker - [Complex:1225875] NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] - v43:[updateContainedComponent] [UpdateTracker:9872480] Update Tracker - [Complex:1225875] NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] - v41:[removeCompartment] [UpdateTracker:9888827] Update Tracker - [Complex:1225875] NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] - v48:[updateContainedComponent] [UpdateTracker:9893012] Update Tracker - [Complex:1225875] NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] - v54:[add_removeHasComponent, modifyName, updateContainedComponent] [UpdateTracker:9894987] Update Tracker - [Complex:1225875] NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] - v58:[updateContainedComponent]
(inferredTo)	[Complex:R-NUL-1181338] Nodal:Nodal Receptor (human-mouse chimera) [plasma membrane]
(input)	[Reaction:R-HSA-1181156] Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL
(physicalEntity)	[CatalystActivity:1181151] protein serine/threonine kinase activity of NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane]