Reactome | CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK

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CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK Show undefined attributes

authored	[InstanceEdit:1168382] May, B, 2010-12-18
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1168634] May, B, 2011-01-03
dbId	1168637
displayName	CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
edited	[InstanceEdit:1168382] May, B, 2010-12-18
eventOf	[Pathway:R-HSA-1169091] Activation of NF-kappaB in B cells - Homo sapiens
followingEvent	[Reaction:R-HSA-1168641] TAK1 associated with the CBM complex phosphorylates IKKbeta - Homo sapiens
inferredFrom	[Reaction:R-GGA-1169563] CARMA1 recruits TAK1 and the IKK complex - Gallus gallus
input	[Complex:R-HSA-168113] CHUK:IKBKB:IKBKG [cytosol] [EntityWithAccessionedSequence:R-HSA-168156] MAP3K7 [cytosol] [Complex:R-HSA-1168622] p-CARMA1:MALT1:p-BCL10 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1169052] Phosphorylation of the CARMA1 linker controls NF-kappaB activation [LiteratureReference:1169522] Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signaling [LiteratureReference:571311] PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
output	[Complex:R-HSA-1168620] p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane]
precedingEvent	[Reaction:R-HSA-1168644] CARMA1 recruits MALT1 and BCL10 forming CBM Complex - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2108988] Wienands, J, 2012-02-11
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1168637
summation	[Summation:1168631] TAK1 and the IKK complex are observed to migrate from the cy...

Referrals

(hasEvent)	[Pathway:R-HSA-1169091] Activation of NF-kappaB in B cells
(precedingEvent)	[Reaction:R-HSA-1168641] TAK1 associated with the CBM complex phosphorylates IKKbeta
(inferredTo)	[Reaction:R-GGA-1169563] CARMA1 recruits TAK1 and the IKK complex

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