Reactome | Regulation of pyruvate metabolism

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Regulation of pyruvate metabolism Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:5462] mitochondrion
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10826443
displayName	Regulation of pyruvate metabolism
eventOf	[Pathway:R-GGA-70268] Pyruvate metabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9607892] regulation of small molecule metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-GGA-204174] Regulation of pyruvate dehydrogenase (PDH) complex - Gallus gallus [Reaction:R-GGA-9861642] NEK1 phosphorylates ME1 - Gallus gallus [Reaction:R-GGA-9861725] PGAM5 dodecamer dephosphorylates p-S336-ME1 - Gallus gallus [Reaction:R-GGA-9861631] ME1 tetramerizes - Gallus gallus [BlackBoxEvent:R-GGA-9861563] CTLH E3 ligase ubiquitinates LDHA - Gallus gallus [BlackBoxEvent:R-GGA-9861640] CTLH E3 ligase ubiquitinates PKM-1 - Gallus gallus
inferredFrom	[Pathway:R-HSA-9861718] Regulation of pyruvate metabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Regulation of pyruvate metabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-9861718
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-70268] Pyruvate metabolism
(inferredTo)	[Pathway:R-HSA-9861718] Regulation of pyruvate metabolism