Reactome | PPP1CC dephosphorylates PLK1

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PPP1CC dephosphorylates PLK1 Show undefined attributes

catalystActivity	[CatalystActivity:10822081] protein serine/threonine phosphatase activity of PPP1CC [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10822083
displayName	PPP1CC dephosphorylates PLK1
eventOf	[Pathway:R-GGA-2500257] Resolution of Sister Chromatid Cohesion - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9853385] PPP1CC dephosphorylates PLK1 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-GGA-3000318] phospho-PLK1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PPP1CC dephosphorylates PLK1
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [EntityWithAccessionedSequence:R-GGA-164603] PLK1 [cytosol]
regulatedBy	[NegativeRegulation:10822084] Negative regulation by 'FIRRM:PPP1CC [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9853385
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2500257] Resolution of Sister Chromatid Cohesion
(inferredTo)	[Reaction:R-HSA-9853385] PPP1CC dephosphorylates PLK1

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