Reactome | Mitochondrial protein degradation

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Mitochondrial protein degradation Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10828455
displayName	Mitochondrial protein degradation
eventOf	[TopLevelPathway:R-GGA-392499] Metabolism of proteins - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1301039] mitochondrial protein catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-9838093] LONP1 binds mitochondrial matrix proteins - Gallus gallus [BlackBoxEvent:R-GGA-9838081] LONP1 degrades mitochondrial matrix proteins - Gallus gallus [Reaction:R-GGA-9837978] LONP1 binds mitochondrial inner membrane proteins - Gallus gallus [BlackBoxEvent:R-GGA-9838004] LONP1 degrades mitochondrial inner membrane proteins - Gallus gallus [Reaction:R-GGA-9839149] AFG3L2 binds mitochondrial matrix proteins - Gallus gallus [BlackBoxEvent:R-GGA-9839105] AFG3L2 degrades mitochondrial matrix proteins - Gallus gallus [Reaction:R-GGA-9838627] AFG3L2 binds mitochondrial inner membrane proteins - Gallus gallus [BlackBoxEvent:R-GGA-9839113] AFG3L2 degrades mitochondrial inner membrane proteins - Gallus gallus [Reaction:R-GGA-9839053] AFG3L2:SPG7 binds SMDT1 (EMRE) - Gallus gallus [BlackBoxEvent:R-GGA-9839059] AFG3L2:SPG7 degrades SMDT1 (EMRE) - Gallus gallus [Reaction:R-GGA-9839073] HTRA2 binds NDUFA13 (GRIM-19) - Gallus gallus [BlackBoxEvent:R-GGA-9839110] HTRA2 degrades NDUFA13 (GRIM-19) - Gallus gallus [BlackBoxEvent:R-GGA-9839072] HTRA2 degrades APP (Amyloid-beta precursor protein) - Gallus gallus
inferredFrom	[Pathway:R-HSA-9837999] Mitochondrial protein degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Mitochondrial protein degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-9837999
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-GGA-392499] Metabolism of proteins
(inferredTo)	[Pathway:R-HSA-9837999] Mitochondrial protein degradation

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