Reactome | IKK? (IKBKE) is ubiquitinated within the activated TLR4

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IKK? (IKBKE) is ubiquitinated within the activated TLR4 Show undefined attributes

category	omitted
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10820509
displayName	IKK? (IKBKE) is ubiquitinated within the activated TLR4
eventOf	[Pathway:R-GGA-9824878] Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7 - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9823939] IKK? (IKBKE) is ubiquitinated within the activated TLR4 - Homo sapiens
input	[Complex:R-GGA-9823936] IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [DefinedSet:R-GGA-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IKK? (IKBKE) is ubiquitinated within the activated TLR4 IKK? (IKBKE) is ubiquitinated within IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
output	[Complex:R-GGA-9823938] K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-GGA-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Gallus gallus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-9823939
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9824878] Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7
(inferredTo)	[BlackBoxEvent:R-HSA-9823939] IKK? (IKBKE) is ubiquitinated within the activated TLR4

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