Reactome | MIB2 ubiquitinates RIPK1 at K377, K604, K634

Schema > BlackBoxEvent > Entries

MIB2 ubiquitinates RIPK1 at K377, K604, K634 Show undefined attributes

catalystActivity	[CatalystActivity:10820220] ubiquitin-protein transferase activity of TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10820222
displayName	MIB2 ubiquitinates RIPK1 at K377, K604, K634
eventOf	[Pathway:R-GGA-5357905] Regulation of TNFR1 signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9796346] MIB2 ubiquitinates RIPK1 at K377, K604, K634 - Homo sapiens
input	[Complex:R-GGA-9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	MIB2 ubiquitinates RIPK1 at K377, K604, K634
output	[Complex:R-GGA-9816109] TNF-?:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] [EntityWithAccessionedSequence:R-GGA-8864160] UBE2D1 [cytosol]
precedingEvent	[Reaction:R-GGA-9796342] MIB2 binds RIPK1 within TNF-?:TNFR1:TRADD:RIPK1:TRAF2 - Gallus gallus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-9796346
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5357905] Regulation of TNFR1 signaling
(inferredTo)	[BlackBoxEvent:R-HSA-9796346] MIB2 ubiquitinates RIPK1 at K377, K604, K634

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