Reactome | SMPD1 converts sphingomyelin to ceramide

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SMPD1 converts sphingomyelin to ceramide Show undefined attributes

catalystActivity	[CatalystActivity:10819704] sphingomyelin phosphodiesterase activity of SMPD1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10819706
displayName	SMPD1 converts sphingomyelin to ceramide
eventOf	[Pathway:R-GGA-9769739] Regulation of clotting cascade - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9769742] SMPD1 converts sphingomyelin to ceramide - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-GGA-9931707] tissue factor : SPHM d18:1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SMPD1 converts sphingomyelin to ceramide Sphingomyelin phosphodiesterase 1 hydrolyses sphingomyelin to ceramide
output	[SimpleEntity:R-ALL-1610735] ChoP [plasma membrane] [EntityWithAccessionedSequence:R-GGA-140762] F3 [plasma membrane] [SimpleEntity:R-ALL-9822560] N-acylsphingosine [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9769742
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9769739] Regulation of clotting cascade
(inferredTo)	[Reaction:R-HSA-9769742] SMPD1 converts sphingomyelin to ceramide

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